| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 6 |
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| Ligand | BDBM50370952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432301 (CHEMBL915562) |
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| IC50 | 45±n/a nM |
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| Citation |  Nagashima, S; Yokota, M; Nakai, E; Kuromitsu, S; Ohga, K; Takeuchi, M; Tsukamoto, S; Ohta, M Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem15:1044-55 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 6 |
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| Name: | Signal transducer and activator of transcription 6 |
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| Synonyms: | STAT6 | STAT6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 94129.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881634 |
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| Residue: | 847 |
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| Sequence: | MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
LRANPSW
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| BDBM50370952 |
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| n/a |
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| Name | BDBM50370952 |
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| Synonyms: | CHEMBL228018 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20ClN5O2 |
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| Mol. Mass. | 397.858 |
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| SMILES | Cc1cccc(Nc2nc(NCCc3ccc(O)c(Cl)c3)ncc2C(N)=O)c1 |
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| Structure | 
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