| Reaction Details |
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 | Report a problem with these data |
| Target | Histidinol dehydrogenase |
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| Ligand | BDBM50267342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_436509 (CHEMBL904815) |
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| IC50 | 150±n/a nM |
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| Citation |  Abdo, MR; Joseph, P; Boigegrain, RA; Liautard, JP; Montero, JL; Köhler, S; Winum, JY Brucella suis histidinol dehydrogenase: synthesis and inhibition studies of a series of substituted benzylic ketones derived from histidine. Bioorg Med Chem15:4427-33 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histidinol dehydrogenase |
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| Name: | Histidinol dehydrogenase |
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| Synonyms: | HISX_BRUSU | hisD |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46060.70 |
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| Organism: | Brucella suis |
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| Description: | ChEMBL_436509 |
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| Residue: | 430 |
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| Sequence: | MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID
LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR
WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG
VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVL
IVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASA
SWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIG
DYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAH
AQSVAIRLNL
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| BDBM50267342 |
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| n/a |
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| Name | BDBM50267342 |
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| Synonyms: | (S)-3-Amino-4-(1H-imidazol-4-yl)-1-(4-methoxy-phenyl)-butan-2-one; dihydrochloride | (S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-methoxyphenyl)butan-2-one dihydrochloride | CHEMBL477467 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17N3O2 |
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| Mol. Mass. | 259.3037 |
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| SMILES | COc1ccc(CC(=O)[C@@H](N)Cc2cnc[nH]2)cc1 |r| |
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| Structure | 
|
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