| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| Ligand | BDBM50214006 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_438956 (CHEMBL889299) |
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| IC50 | 1800±n/a nM |
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| Citation |  Pietranico, SL; Foley, LH; Huby, N; Yun, W; Dunten, P; Vermeulen, J; Wang, P; Toth, K; Ramsey, G; Gubler, ML; Wertheimer, SJ C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg Med Chem Lett17:3835-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| Name: | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
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| Synonyms: | PCK1 | PCKGC_HUMAN | PEPCK1 | Phosphoenolpyruvate carboxykinase cytosolic |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69189.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_438956 |
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| Residue: | 622 |
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| Sequence: | MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQM
EEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEE
DFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPV
LEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSL
LGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSL
PGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNV
AETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAW
ESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPF
AMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWM
FNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQV
NADLPCEIEREILALKQRISQM
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| BDBM50214006 |
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| n/a |
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| Name | BDBM50214006 |
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| Synonyms: | CHEMBL397513 | N-(4-((1-(2-fluorobenzyl)-3-(cyclopropylmethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-2,2,2-trifluoroacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21F4N5O3 |
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| Mol. Mass. | 515.4596 |
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| SMILES | Fc1ccccc1Cn1c(=O)n(CC2CC2)c2nc(Cc3ccc(NC(=O)C(F)(F)F)cc3)[nH]c2c1=O |
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| Structure | 
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