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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50217442 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_444681 (CHEMBL894930) | ||
| IC50 | 330±n/a nM | ||
| Citation |  Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem50:3825-40 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
| ||
| BDBM50217442 | |||
| n/a | |||
| Name | BDBM50217442 | ||
| Synonyms: | CHEMBL244407 | cis-2-[4-(3-adamantan-1-ylureido)cyclohexyloxy]benzoic acid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H32N2O4 | ||
| Mol. Mass. | 412.5219 | ||
| SMILES | OC(=O)c1ccccc1O[C@@H]1CC[C@@H](CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |wU:13.17,10.10,TLB:19:20:23.22.27:25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20,19:20:23:27.26.25,(25.93,-36.65,;25.22,-38.01,;23.68,-38.07,;26.04,-39.31,;27.57,-39.25,;28.4,-40.56,;27.68,-41.92,;26.14,-41.98,;25.32,-40.67,;23.79,-40.73,;23.06,-42.09,;21.52,-42.15,;20.8,-43.51,;21.62,-44.8,;23.16,-44.75,;23.88,-43.39,;20.9,-46.17,;19.36,-46.23,;18.54,-44.93,;18.65,-47.59,;17.11,-47.65,;16.09,-48.93,;14.69,-48.37,;13.19,-48.79,;14.38,-47.51,;14.38,-46.02,;15.72,-45.55,;14.68,-46.78,;17.12,-46.13,;15.71,-48,)| | ||
| Structure | 
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