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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50217447 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_444681 (CHEMBL894930) | ||
| IC50 | 76±n/a nM | ||
| Citation |  Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem50:3825-40 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
| ||
| BDBM50217447 | |||
| n/a | |||
| Name | BDBM50217447 | ||
| Synonyms: | CHEMBL242257 | cis-1-adamantan-1-yl-3-(4-hydroxycyclohexyl)urea | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H28N2O2 | ||
| Mol. Mass. | 292.4164 | ||
| SMILES | O[C@H]1CC[C@H](CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |wD:4.7,1.0,TLB:10:11:14.13.18:16,THB:12:13:16:20.11.19,12:11:14.13.18:16,19:11:14:18.17.16,19:17:14:20.12.11,10:11:14:18.17.16,(27.11,6.8,;26.39,5.44,;24.85,5.38,;24.12,4.02,;24.94,2.73,;26.49,2.78,;27.21,4.14,;24.23,1.36,;22.69,1.3,;21.87,2.6,;21.97,-.06,;20.43,-.12,;19.42,-1.4,;18.01,-.84,;16.51,-1.26,;17.71,.02,;17.7,1.51,;19.05,1.98,;18.01,.75,;20.45,1.4,;19.04,-.47,)| | ||
| Structure | 
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