Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bifunctional epoxide hydrolase 2 | ||
| Ligand | BDBM50217452 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_444681 (CHEMBL894930) | ||
| IC50 | 8300±n/a nM | ||
| Citation |  Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem50:3825-40 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bifunctional epoxide hydrolase 2 | |||
| Name: | Bifunctional epoxide hydrolase 2 | ||
| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 62613.07 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34913 | ||
| Residue: | 555 | ||
| Sequence: |
| ||
| BDBM50217452 | |||
| n/a | |||
| Name | BDBM50217452 | ||
| Synonyms: | CHEMBL245006 | cis-4-{4-[3-(4-carboxyphenyl)ureido]cyclohexyloxy}benzoicacid | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22N2O6 | ||
| Mol. Mass. | 398.4092 | ||
| SMILES | OC(=O)c1ccc(NC(=O)N[C@H]2CC[C@H](CC2)Oc2cccc(c2)C(O)=O)cc1 |wU:11.10,14.17,(-8.15,-12.39,;-7.32,-13.69,;-8.04,-15.06,;-5.78,-13.63,;-5.06,-12.26,;-3.53,-12.2,;-2.7,-13.51,;-1.16,-13.45,;-.45,-12.08,;-1.28,-10.78,;1.09,-12.02,;1.8,-10.66,;.99,-9.36,;1.71,-8,;3.25,-7.94,;4.07,-9.25,;3.36,-10.6,;3.98,-6.58,;5.52,-6.53,;6.23,-5.17,;7.76,-5.1,;8.59,-6.42,;7.87,-7.77,;6.33,-7.83,;8.69,-9.08,;7.98,-10.44,;10.23,-9.03,;-3.41,-14.87,;-4.95,-14.94,)| | ||
| Structure | 
| ||