| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase TEM |
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| Ligand | BDBM50218932 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_445224 (CHEMBL894371) |
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| IC50 | 12±n/a nM |
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| Citation |  Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity. J Med Chem50:4113-21 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase TEM |
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| Name: | Beta-lactamase TEM |
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| Synonyms: | BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla |
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| Type: | Enzyme |
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| Mol. Mass.: | 31512.33 |
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| Organism: | Escherichia coli |
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| Description: | P62593 |
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| Residue: | 286 |
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| Sequence: | MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
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| BDBM50218932 |
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| n/a |
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| Name | BDBM50218932 |
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| Synonyms: | CHEMBL396998 | sodium (8R,9R)-10(S)-[1(R)-hydroxyethyl]-4(R)-butoxy-11-oxo-1-azatricyclo[7.2.0 .03,8]undec-2-enecarboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22NO4 |
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| Mol. Mass. | 304.3614 |
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| SMILES | CCCCO[C@@H]1CCC[C@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 |t:21| |
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| Structure | 
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