| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase SHV-1 |
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| Ligand | BDBM50218939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_445225 (CHEMBL894369) |
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| IC50 | 206±n/a nM |
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| Citation |  Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity. J Med Chem50:4113-21 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase SHV-1 |
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| Name: | Beta-lactamase SHV-1 |
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| Synonyms: | BLA1_KLEPN | Beta-lactamase SHV-1 | SHV-1 beta-lactamase | bla | shv1 |
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| Type: | Protein |
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| Mol. Mass.: | 31226.68 |
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| Organism: | Klebsiella pneumoniae (Enterobacteria) |
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| Description: | 4R3B |
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| Residue: | 286 |
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| Sequence: | MRYIRLCIISLLATLPLAVHASPQPLEQIKLSESQLSGRVGMIEMDLASGRTLTAWRADE
RFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCA
AAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARG
IVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
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| BDBM50218939 |
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| n/a |
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| Name | BDBM50218939 |
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| Synonyms: | CHEMBL230332 | sodium (5S,8aS,8bR)-5-butoxy-1-eth-(E)-ylidene-2-oxo-1,2,5,6,7,8,8a,8b-octahydro-azeto[2,1-a]isoindole-4-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22NO4 |
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| Mol. Mass. | 304.3614 |
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| SMILES | CCCCO[C@H]1CCC[C@@H]2[C@H]3N(C(=O)\C3=C\C)C(C([O-])=O)=C12 |t:21| |
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| Structure | 
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