| Reaction Details |
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 | Report a problem with these data |
| Target | Trans-2-enoyl-ACP reductase II |
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| Ligand | BDBM8726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_445899 (CHEMBL896189) |
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| IC50 | >32000±n/a nM |
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| Citation |  Kitagawa, H; Ozawa, T; Takahata, S; Iida, M; Saito, J; Yamada, M Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK. J Med Chem50:4710-20 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Trans-2-enoyl-ACP reductase II |
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| Name: | Trans-2-enoyl-ACP reductase II |
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| Synonyms: | Enoyl-ACP Reductase (FabK) | FabK | NADH-dependent, FAD-containing enoyl-ACP | trans-2-enoyl-ACP reductase II |
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| Type: | Enzyme |
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| Mol. Mass.: | 34170.89 |
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| Organism: | Streptococcus pneumoniae |
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| Description: | n/a |
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| Residue: | 324 |
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| Sequence: | MKTRITELLKIDYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKS
LTDKPFGVNIMLLSPFVEDIVDLVIEEGVKVVTTGAGNPSKYMERFHEAGIIVIPVVPSV
ALAKRMEKIGADAVIAEGMEAGGHIGKLTTMTLVRQVATAISIPVIAAGGIADGEGAAAG
FMLGAEAVQVGTRFVVAKESNAHPNYKEKILKARDIDTTISAQHFGHAVRAIKNQLTRDF
ELAEKDAFKQEDPDLEIFEQMGAGALAKAVVHGDVDGGSVMAGQIAGLVSKEETAEEILK
DLYYGAAKKIQEEASRWTGVVRND
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| BDBM8726 |
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| n/a |
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| Name | BDBM8726 |
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| Synonyms: | 5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H7Cl3O2 |
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| Mol. Mass. | 289.542 |
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| SMILES | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
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| Structure | 
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