| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Ligand | BDBM50220630 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457362 (CHEMBL940953) |
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| IC50 | 3000±n/a nM |
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| Citation |  Bhowruth, V; Brown, AK; Senior, SJ; Snaith, JS; Besra, GS Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library. Bioorg Med Chem Lett17:5643-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Synonyms: | β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH |
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| Type: | Enzyme |
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| Mol. Mass.: | 34865.07 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WNG3 |
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| Residue: | 335 |
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| Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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| BDBM50220630 |
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| n/a |
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| Name | BDBM50220630 |
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| Synonyms: | 5-(4-methoxycarbonyl-biphenyl-4-ylmethyl)-4-hydroxy-3,5-dimethyl-5H-thiophen-2-one | CHEMBL250431 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20O4S |
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| Mol. Mass. | 368.446 |
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| SMILES | COC(=O)c1ccc(cc1)-c1ccc(CC2(C)SC(=O)C(C)C2=O)cc1 |
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| Structure | 
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