BindingDB PrimarySearch

Found 71 hits with Last Name = 'brown' and Initial = 'ak'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50477824 (CHEMBL252766) Show SMILES CSc1ccc2nc(cn2c1)-c1ccc(cc1)N(C)C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue				J Med Chem 51: 148-58 (2008) Article DOI: 10.1021/jm700970s BindingDB Entry DOI: 10.7270/Q2BG2RSQ
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50122787 (2-(4'-dimethylaminophenyl)-6-iodoimidazo[1,2-a]pyr...) Show SMILES CN(C)c1ccc(cc1)-c1cn2cc(I)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue				J Med Chem 51: 148-58 (2008) Article DOI: 10.1021/jm700970s BindingDB Entry DOI: 10.7270/Q2BG2RSQ
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50477826 (CHEMBL252765) Show SMILES CNc1ccc(cc1)-c1cn2cc(SC)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue				J Med Chem 51: 148-58 (2008) Article DOI: 10.1021/jm700970s BindingDB Entry DOI: 10.7270/Q2BG2RSQ
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50477823 (CHEMBL252969) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	205	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue				J Med Chem 51: 148-58 (2008) Article DOI: 10.1021/jm700970s BindingDB Entry DOI: 10.7270/Q2BG2RSQ
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Amyloid-beta precursor protein (Homo sapiens (Human))	BDBM50477825 (CHEMBL254850) Show SMILES CSc1ccc2nc(cn2c1)-c1ccc(N)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	377	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue				J Med Chem 51: 148-58 (2008) Article DOI: 10.1021/jm700970s BindingDB Entry DOI: 10.7270/Q2BG2RSQ
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity at mGluR1				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [125I]pindolol from adrenergic beta-2 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]DADLE from delta opioid receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2B adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]cholidine from adrenergic alpha-2B receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]QNB from muscarinic M1 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]ketanserin from 5HT2A receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-1 adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [125I]pindolol from adrenergic beta-1 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]WIN-35428 from DAT				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1D (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]GR-125743 from 5HT1D receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 5A (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT5A receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from dopamine D3 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]QNB from muscarinic M3 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(1B) dopamine receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of radiolabeled SKF-38393 from dopamine D5 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]diprenorphine from mu opioid receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity at mGluR4				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1B (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]GR-125743 from 5HT1B receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT2B receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]cholidine from adrenergic alpha2A receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent noradrenaline transporter (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]nisoxitine from NET				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]QNB from muscarinic M4 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]citalopram from SERT				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to from histamine H2 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1B adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from adrenergic alpha-1B receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT7 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]mesulergine from 5HT2C receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]QNB from muscarinic M2 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from dopamine D4 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity at mGluR6				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity at mGluR8				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]bremazocine from kappa opioid receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H3 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]cholidine from adrenergic alpha-2C receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]QNB from muscarinic M5 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H1 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from dopamine D2 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1A adrenergic receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from adrenergic alpha-1A receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to histamine H4 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity to sigma1 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]LSD from 5HT6 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]5-HT from 5HT1E receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Binding affinity at mGluR2				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]SCH-23390 from dopamine D1 receptor				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00100	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Activity at human recombinant mGluR5 in CHO cells assessed as inhibition of quisqualate-stimulated phosphoinositide hydrolysis				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50215552 (3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...) Show SMILES FCc1nc(cs1)C#Cc1cc(F)cc(c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0360	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Mental Health Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5 in rat brain membrane				J Med Chem 50: 3256-66 (2007) Article DOI: 10.1021/jm0701268 BindingDB Entry DOI: 10.7270/Q2FB52NB
National Institute of Mental Health Curated by ChEMBL					More data for this Ligand-Target Pair

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