| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage colony-stimulating factor 1 receptor |
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| Ligand | BDBM50372158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464762 (CHEMBL930128) |
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| IC50 | 2±n/a nM |
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| Citation |  Dai, Y; Hartandi, K; Soni, NB; Pease, LJ; Reuter, DR; Olson, AM; Osterling, DJ; Doktor, SZ; Albert, DH; Bouska, JJ; Glaser, KB; Marcotte, PA; Stewart, KD; Davidsen, SK; Michaelides, MR Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. Bioorg Med Chem Lett18:386-90 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage colony-stimulating factor 1 receptor |
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| Name: | Macrophage colony-stimulating factor 1 receptor |
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| Synonyms: | CSF1R | CSF1R_HUMAN | FMS | Fms proto-oncogene | Macrophage colony stimulating factor receptor | Macrophage colony-stimulating factor 1 receptor (FMS) | Macrophage colony-stimulating factor 1 receptor (c-FMS) | Macrophage colony-stimulating factor 1 receptor (cFMS) | Proto-oncogene c-Fms | Tyrosine Kinase CSF1-R | c-fms | cFMS |
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| Type: | Protein |
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| Mol. Mass.: | 107979.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07333 |
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| Residue: | 972 |
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| Sequence: | MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTL
YSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFED
QDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSAL
MGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHN
NTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAY
LNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTY
RHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCA
ASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHN
QTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKY
KQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEAT
AFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVL
VITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGV
DTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVA
ARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWS
YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR
PTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIA
QPLLQPNNYQFC
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| BDBM50372158 |
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| n/a |
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| Name | BDBM50372158 |
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| Synonyms: | CHEMBL404367 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N6O |
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| Mol. Mass. | 372.4231 |
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| SMILES | Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cncc3n(C)nc(N)c23)c1 |
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| Structure | 
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