| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Liver carboxylesterase 1 |
|---|
| Ligand | BDBM50372373 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_464891 (CHEMBL949090) |
|---|
| IC50 | 4.5±n/a nM |
|---|
| Citation |  Kimball, FS; Romero, FA; Ezzili, C; Garfunkle, J; Rayl, TJ; Hochstatter, DG; Hwang, I; Boger, DL Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem51:937-47 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Liver carboxylesterase 1 |
|---|
| Name: | Liver carboxylesterase 1 |
|---|
| Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 62520.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 567 |
|---|
| Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
|
|
|
|---|
| BDBM50372373 |
|---|
| n/a |
|---|
| Name | BDBM50372373 |
|---|
| Synonyms: | CHEMBL261172 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H15NO2 |
|---|
| Mol. Mass. | 277.3172 |
|---|
| SMILES | O=C(CCc1ccc(cc1)-c1ccccc1)c1ncco1 |
|---|
| Structure | 
|
|---|
Search and Browse
