| Reaction Details |
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 | Report a problem with these data |
| Target | Farnesyl pyrophosphate synthase |
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| Ligand | BDBM50098380 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_466620 (CHEMBL924794) |
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| Ki | 48.2±n/a nM |
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| Citation |  Dunford, JE; Kwaasi, AA; Rogers, MJ; Barnett, BL; Ebetino, FH; Russell, RG; Oppermann, U; Kavanagh, KL Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem51:2187-95 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Farnesyl pyrophosphate synthase |
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| Name: | Farnesyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48272.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14324 |
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| Residue: | 419 |
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| Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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| BDBM50098380 |
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| n/a |
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| Name | BDBM50098380 |
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| Synonyms: | (5-Amino-1-hydroxy-1-phosphono-pentyl)-phosphonic acid | 5-Hydroxy-5,5-bis-phosphono-pentyl-ammonium | 5-amino-1-hydroxypentane-1,1-diyldiphosphonic acid | 5-aminopentane-1-hydroxy-1,1-bisphosphonate | CHEMBL298771 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H15NO7P2 |
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| Mol. Mass. | 263.1226 |
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| SMILES | NCCCCC(O)(P(O)(O)=O)P(O)(O)=O |
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| Structure | 
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