Reaction Details |
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Target | Mitogen-activated protein kinase 8 |
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Ligand | BDBM50373215 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_467340 (CHEMBL934566) |
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IC50 | 2.6±n/a nM |
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Citation | Asano, Y; Kitamura, S; Ohra, T; Aso, K; Igata, H; Tamura, T; Kawamoto, T; Tanaka, T; Sogabe, S; Matsumoto, S; Yamaguchi, M; Kimura, H; Itoh, F Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1). Bioorg Med Chem16:4715-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 8 |
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Name: | Mitogen-activated protein kinase 8 |
Synonyms: | Jnk1 | MK08_RAT | Mapk8 | Prkm8 |
Type: | PROTEIN |
Mol. Mass.: | 46809.57 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_475208 |
Residue: | 411 |
Sequence: | MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
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BDBM50373215 |
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n/a |
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Name | BDBM50373215 |
Synonyms: | CHEMBL259060 |
Type | Small organic molecule |
Emp. Form. | C25H20BrNO5S |
Mol. Mass. | 526.399 |
SMILES | COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(cc1)S(C)(=O)=O |
Structure |
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