| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Ligand | BDBM50373215 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_467354 (CHEMBL934580) |
|---|
| IC50 | >11000±n/a nM |
|---|
| Citation |  Asano, Y; Kitamura, S; Ohra, T; Aso, K; Igata, H; Tamura, T; Kawamoto, T; Tanaka, T; Sogabe, S; Matsumoto, S; Yamaguchi, M; Kimura, H; Itoh, F Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1). Bioorg Med Chem16:4715-32 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
|---|
| Synonyms: | I-kappa-B Kinase 2 (IKK-beta) | I-kappa-B kinase 2 | I-kappa-B-kinase beta | I-kappa-B-kinase beta (IKKB) | IKBKB | IKK-B | IKK-beta | IKK2 | IKK2/IKK1 | IKKB | IKKB_HUMAN | Inhibitor of NF-kappa-B kinase alpha/beta | Inhibitor of nuclear factor kappa B kinase beta subunit | NFKBIKB | Nuclear factor NF-kappa-B inhibitor kinase beta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 86554.39 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | GST-tagged IKK-2 was expressed in High Five cells and purified. |
|---|
| Residue: | 756 |
|---|
| Sequence: | MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLA
LIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRN
LAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLE
NAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
|
|
|
|---|
| BDBM50373215 |
|---|
| n/a |
|---|
| Name | BDBM50373215 |
|---|
| Synonyms: | CHEMBL259060 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H20BrNO5S |
|---|
| Mol. Mass. | 526.399 |
|---|
| SMILES | COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(cc1)S(C)(=O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
