Reaction Details |
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Target | RAC-beta serine/threonine-protein kinase |
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Ligand | BDBM50373459 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_467870 (CHEMBL937420) |
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IC50 | 730±n/a nM |
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Citation | Bilodeau, MT; Balitza, AE; Hoffman, JM; Manley, PJ; Barnett, SF; Defeo-Jones, D; Haskell, K; Jones, RE; Leander, K; Robinson, RG; Smith, AM; Huber, HE; Hartman, GD Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model. Bioorg Med Chem Lett18:3178-82 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-beta serine/threonine-protein kinase |
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Name: | RAC-beta serine/threonine-protein kinase |
Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
Type: | Enzyme |
Mol. Mass.: | 55766.64 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 481 |
Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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BDBM50373459 |
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n/a |
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Name | BDBM50373459 |
Synonyms: | CHEMBL258696 |
Type | Small organic molecule |
Emp. Form. | C40H43N7O2 |
Mol. Mass. | 653.8151 |
SMILES | CCN(CC)CCNC(=O)c1ccc2nc(-c3ccccc3)c(nc2c1)-c1ccc(CN2CCC(CC2)n2c3ccccc3[nH]c2=O)cc1 |
Structure |
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