Compile Data Set for Download or QSAR

Found 104 hits with Last Name = 'balitza' and Initial = 'ae'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5284 (4-{[4-(Methylsulfonyl)piperazin-1-yl]methyl}-N-(5-...) Show SMILES CS(=O)(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C20H23N5O2S2/c1-29(26,27)25-11-9-24(10-12-25)15-16-7-8-21-19(13-16)23-20-22-14-18(28-20)17-5-3-2-4-6-17/h2-8,13-14H,9-12,15H2,1H3,(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5282 ((5-Phenylthiazol-2-yl)(4-pyrrolidin-1-ylmethylpyri...) Show SMILES C(N1CCCC1)c1ccnc(Nc2ncc(s2)-c2ccccc2)c1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-12-15(8-9-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCC(CC4)c4nnc([nH]4)-c4ccccn4)cc3)c(cc12)-c1ccccc1 Show InChI InChI=1S/C33H29N7O/c41-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)13-17-35-33)24-11-9-22(10-12-24)21-40-18-14-25(15-19-40)31-37-32(39-38-31)29-8-4-5-16-34-29/h1-13,16-17,20,25H,14-15,18-19,21H2,(H,35,41)(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5384 (2,4-Disubstituted Pyrimidine 2h | N-(3,5-dimethoxy...) Show SMILES COc1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(OC)c1 Show InChI InChI=1S/C21H19N5O2/c1-27-17-12-16(13-18(14-17)28-2)24-21-23-9-8-19(25-21)26-11-10-22-20(26)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5389 (2,4-Disubstituted Pyrimidine 3a | N-[3-methyl-5-(t...) Show SMILES Cc1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H16F3N5/c1-14-11-16(21(22,23)24)13-17(12-14)27-20-26-8-7-18(28-20)29-10-9-25-19(29)15-5-3-2-4-6-15/h2-13H,1H3,(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373461 (CHEMBL259753) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2cccnc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-7-24(8-3-1)27-21-30-28(10-6-18-35-30)36-31(27)25-13-11-23(12-14-25)22-40-19-15-26(16-20-40)32-37-33(39-38-32)29-9-4-5-17-34-29/h1-14,17-18,21,26H,15-16,19-20,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5281 (5-phenyl-N-[5-(pyrrolidin-1-ylmethyl)pyridin-2-yl]...) Show SMILES C(N1CCCC1)c1ccc(Nc2ncc(s2)-c2ccccc2)nc1 Show InChI InChI=1S/C19H20N4S/c1-2-6-16(7-3-1)17-13-21-19(24-17)22-18-9-8-15(12-20-18)14-23-10-4-5-11-23/h1-3,6-9,12-13H,4-5,10-11,14H2,(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5380 (2,4-Disubstituted Pyrimidine 2d | N-(3,5-dimethylp...) Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C21H19N5/c1-15-12-16(2)14-18(13-15)24-21-23-9-8-19(25-21)26-11-10-22-20(26)17-6-4-3-5-7-17/h3-14H,1-2H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5280 (5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...) Show SMILES N(c1ncc(s1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)12-10-16-14(18-12)17-13-8-4-5-9-15-13/h1-10H,(H,15,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5292 (2-({4-[(4-methanesulfonylpiperidin-1-yl)methyl]pyr...) Show SMILES CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N5O2S2/c1-25(22,23)14-3-6-21(7-4-14)11-12-2-5-18-15(8-12)20-16-19-10-13(9-17)24-16/h2,5,8,10,14H,3-4,6-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373462 (CHEMBL259967) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2ccncc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-6-24(7-3-1)28-20-27-21-34-17-13-29(27)36-31(28)25-11-9-23(10-12-25)22-40-18-14-26(15-19-40)32-37-33(39-38-32)30-8-4-5-16-35-30/h1-13,16-17,20-21,26H,14-15,18-19,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5288 (4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...) Show SMILES NC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C15H17N7OS/c16-8-12-9-19-15(24-12)20-13-7-11(1-2-18-13)10-21-3-5-22(6-4-21)14(17)23/h1-2,7,9H,3-6,10H2,(H2,17,23)(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5287 (2-(4-Morpholin-4-ylmethylpyridin-2-ylamino)thiazol...) Show SMILES N#Cc1cnc(Nc2cc(CN3CCOCC3)ccn2)s1 Show InChI InChI=1S/C14H15N5OS/c15-8-12-9-17-14(21-12)18-13-7-11(1-2-16-13)10-19-3-5-20-6-4-19/h1-2,7,9H,3-6,10H2,(H,16,17,18)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5283 (1-[4-({2-[(5-phenyl-1,3-thiazol-2-yl)amino]pyridin...) Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)-c3ccccc3)c2)CC1 Show InChI InChI=1S/C21H23N5OS/c1-16(27)26-11-9-25(10-12-26)15-17-7-8-22-20(13-17)24-21-23-14-19(28-21)18-5-3-2-4-6-18/h2-8,13-14H,9-12,15H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5291 (2-[(4-{[4-(2-hydroxyacetyl)piperazin-1-yl]methyl}p...) Show SMILES OCC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H18N6O2S/c17-8-13-9-19-16(25-13)20-14-7-12(1-2-18-14)10-21-3-5-22(6-4-21)15(24)11-23/h1-2,7,9,23H,3-6,10-11H2,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5391 ((3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)pyrimid...) Show SMILES Cc1cc(CO)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C21H19N5O/c1-15-11-16(14-27)13-18(12-15)24-21-23-8-7-19(25-21)26-10-9-22-20(26)17-5-3-2-4-6-17/h2-13,27H,14H2,1H3,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5289 (4-({2-[(5-Cyano-1,3-thiazol-2-yl)amino]-4-pyridiny...) Show SMILES CN(C)C(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C17H21N7OS/c1-22(2)17(25)24-7-5-23(6-8-24)12-13-3-4-19-15(9-13)21-16-20-11-14(10-18)26-16/h3-4,9,11H,5-8,12H2,1-2H3,(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5387 (2,4-Disubstituted Pyrimidine 2k | 4-(2-phenyl-1H-i...) Show SMILES FC(F)(F)c1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H14F3N5/c21-20(22,23)15-7-4-8-16(13-15)26-19-25-10-9-17(27-19)28-12-11-24-18(28)14-5-2-1-3-6-14/h1-13H,(H,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5293 (4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]-3-methylpy...) Show SMILES CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2C)CC1 Show InChI InChI=1S/C17H21N7OS/c1-12-13(11-23-5-7-24(8-6-23)17(25)19-2)3-4-20-15(12)22-16-21-10-14(9-18)26-16/h3-4,10H,5-8,11H2,1-2H3,(H,19,25)(H,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5290 (4-({2-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-4-y...) Show SMILES CNC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N7OS/c1-18-16(24)23-6-4-22(5-7-23)11-12-2-3-19-14(8-12)21-15-20-10-13(9-17)25-15/h2-3,8,10H,4-7,11H2,1H3,(H,18,24)(H,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5307 (1-methanesulfonyl-4-[(4-{3-phenylimidazo[1,2-a]pyr...) Show SMILES CS(=O)(=O)N1CCN(Cc2ccc(cc2)-c2ccn3c(cnc3c2)-c2ccccc2)CC1 Show InChI InChI=1S/C25H26N4O2S/c1-32(30,31)28-15-13-27(14-16-28)19-20-7-9-21(10-8-20)23-11-12-29-24(18-26-25(29)17-23)22-5-3-2-4-6-22/h2-12,17-18H,13-16,19H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5285 (2-({4-[(4-acetylpiperazin-1-yl)methyl]pyridin-2-yl...) Show SMILES CC(=O)N1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H18N6OS/c1-12(23)22-6-4-21(5-7-22)11-13-2-3-18-15(8-13)20-16-19-10-14(9-17)24-16/h2-3,8,10H,4-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5286 (2-(4-Piperazin-1-ylmethylpyridin-2-ylamino)thiazol...) Show SMILES N#Cc1cnc(Nc2cc(CN3CCNCC3)ccn2)s1 Show InChI InChI=1S/C14H16N6S/c15-8-12-9-18-14(21-12)19-13-7-11(1-2-17-13)10-20-5-3-16-4-6-20/h1-2,7,9,16H,3-6,10H2,(H,17,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCC(CC4)c4nnc([nH]4)-c4ccccn4)cc3)c(cc12)-c1ccccc1 Show InChI InChI=1S/C33H29N7O/c41-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)13-17-35-33)24-11-9-22(10-12-24)21-40-18-14-25(15-19-40)31-37-32(39-38-31)29-8-4-5-16-34-29/h1-13,16-17,20,25H,14-15,18-19,21H2,(H,35,41)(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5378 (2,4-Disubstituted Pyrimidine 2b | N-(3-methylpheny...) Show SMILES Cc1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H17N5/c1-15-6-5-9-17(14-15)23-20-22-11-10-18(24-20)25-13-12-21-19(25)16-7-3-2-4-8-16/h2-14H,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5382 (2,4-Disubstituted Pyrimidine 2f | N-(3-methoxyphen...) Show SMILES COc1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C20H17N5O/c1-26-17-9-5-8-16(14-17)23-20-22-11-10-18(24-20)25-13-12-21-19(25)15-6-3-2-4-7-15/h2-14H,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373462 (CHEMBL259967) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2ccncc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-6-24(7-3-1)28-20-27-21-34-17-13-29(27)36-31(28)25-11-9-23(10-12-25)22-40-18-14-26(15-19-40)32-37-33(39-38-32)30-8-4-5-16-35-30/h1-13,16-17,20-21,26H,14-15,18-19,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373463 (CHEMBL259968) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2cnccc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-6-24(7-3-1)28-20-27-13-17-34-21-30(27)36-31(28)25-11-9-23(10-12-25)22-40-18-14-26(15-19-40)32-37-33(39-38-32)29-8-4-5-16-35-29/h1-13,16-17,20-21,26H,14-15,18-19,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5385 (2,4-Disubstituted Pyrimidine 2i | N-(3-chloropheny...) Show SMILES Clc1cccc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C19H14ClN5/c20-15-7-4-8-16(13-15)23-19-22-10-9-17(24-19)25-12-11-21-18(25)14-5-2-1-3-6-14/h1-13H,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5386 (2,4-Disubstituted Pyrimidine 2j | N-(3,5-dichlorop...) Show SMILES Clc1cc(Cl)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1 Show InChI InChI=1S/C19H13Cl2N5/c20-14-10-15(21)12-16(11-14)24-19-23-7-6-17(25-19)26-9-8-22-18(26)13-4-2-1-3-5-13/h1-12H,(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5308 (4-{3-phenylimidazo[1,2-a]pyridin-7-yl}-1-[3-(piper...) Show SMILES O=c1cc(ccn1CCCN1CCCCC1)-c1ccn2c(cnc2c1)-c1ccccc1 Show InChI InChI=1S/C26H28N4O/c31-26-19-23(10-16-29(26)15-7-14-28-12-5-2-6-13-28)22-11-17-30-24(20-27-25(30)18-22)21-8-3-1-4-9-21/h1,3-4,8-11,16-20H,2,5-7,12-15H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373461 (CHEMBL259753) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2cccnc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-7-24(8-3-1)27-21-30-28(10-6-18-35-30)36-31(27)25-13-11-23(12-14-25)22-40-19-15-26(16-20-40)32-37-33(39-38-32)29-9-4-5-17-34-29/h1-14,17-18,21,26H,15-16,19-20,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373463 (CHEMBL259968) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2cnccc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-6-24(7-3-1)28-20-27-13-17-34-21-30(27)36-31(28)25-11-9-23(10-12-25)22-40-18-14-26(15-19-40)32-37-33(39-38-32)29-8-4-5-16-35-29/h1-13,16-17,20-21,26H,14-15,18-19,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5392 (1-{4-[(3-methyl-5-{[4-(2-phenyl-1H-imidazol-1-yl)p...) Show SMILES CC(=O)N1CCN(Cc2cc(C)cc(Nc3nccc(n3)-n3ccnc3-c3ccccc3)c2)CC1 Show InChI InChI=1S/C27H29N7O/c1-20-16-22(19-32-12-14-33(15-13-32)21(2)35)18-24(17-20)30-27-29-9-8-25(31-27)34-11-10-28-26(34)23-6-4-3-5-7-23/h3-11,16-18H,12-15,19H2,1-2H3,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373465 (CHEMBL260184) Show SMILES O=c1ccc(c[nH]1)-c1cc([nH]n1)C1CCN(Cc2ccc(cc2)-c2nc3ncccc3cc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H30N6O/c41-32-13-12-28(21-36-32)31-20-30(38-39-31)25-14-17-40(18-15-25)22-23-8-10-26(11-9-23)33-29(24-5-2-1-3-6-24)19-27-7-4-16-35-34(27)37-33/h1-13,16,19-21,25H,14-15,17-18,22H2,(H,36,41)(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50256713 (3-phenyl-2-(4-((4-(5-(pyridin-2-yl)-1H-1,2,4-triaz...) Show SMILES O=c1[nH]ccc2nc(-c3ccc(CN4CCC(CC4)c4nnc([nH]4)-c4ccccn4)cc3)c(cc12)-c1ccccc1 Show InChI InChI=1S/C33H29N7O/c41-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)13-17-35-33)24-11-9-22(10-12-24)21-40-18-14-25(15-19-40)31-37-32(39-38-31)29-8-4-5-16-34-29/h1-13,16-17,20,25H,14-15,18-19,21H2,(H,35,41)(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5301 (2-{7-phenylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazol...) Show SMILES c1csc(n1)-c1cnc2cc(ccn12)-c1ccccc1 Show InChI InChI=1S/C16H11N3S/c1-2-4-12(5-3-1)13-6-8-19-14(11-18-15(19)10-13)16-17-7-9-20-16/h1-11H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373466 (CHEMBL259982) Show SMILES C(N1CCC(CC1)c1cc(n[nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2ncccc2cc1-c1ccccc1 Show InChI InChI=1S/C34H30N6/c1-2-7-25(8-3-1)29-21-28-9-6-18-36-34(28)37-33(29)27-13-11-24(12-14-27)23-40-19-15-26(16-20-40)31-22-32(39-38-31)30-10-4-5-17-35-30/h1-14,17-18,21-22,26H,15-16,19-20,23H2,(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373464 (CHEMBL260670) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2ncccc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-7-24(8-3-1)28-21-27-9-6-18-35-31(27)36-30(28)25-13-11-23(12-14-25)22-40-19-15-26(16-20-40)32-37-33(39-38-32)29-10-4-5-17-34-29/h1-14,17-18,21,26H,15-16,19-20,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5303 (4-{7-phenylimidazo[1,2-a]pyridin-3-yl}-1,2-thiazol...) Show SMILES c1nscc1-c1cnc2cc(ccn12)-c1ccccc1 Show InChI InChI=1S/C16H11N3S/c1-2-4-12(5-3-1)13-6-7-19-15(10-17-16(19)8-13)14-9-18-20-11-14/h1-11H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5305 (N-methyl-4-[(4-{3-phenylimidazo[1,2-a]pyridin-7-yl...) Show SMILES CNC(=O)N1CCN(Cc2ccc(cc2)-c2ccn3c(cnc3c2)-c2ccccc2)CC1 Show InChI InChI=1S/C26H27N5O/c1-27-26(32)30-15-13-29(14-16-30)19-20-7-9-21(10-8-20)23-11-12-31-24(18-28-25(31)17-23)22-5-3-2-4-6-22/h2-12,17-18H,13-16,19H2,1H3,(H,27,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM15169 (1-{1-[(4-{7-phenyl-1H-imidazo[4,5-g]quinoxalin-6-y...) Show SMILES O=c1[nH]c2ccccc2n1C1CCN(Cc2ccc(cc2)-c2nc3cc4[nH]cnc4cc3nc2-c2ccccc2)CC1 Show InChI InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5311 (1-(3-{3-[(dimethylamino)methyl]piperidin-1-yl}prop...) Show SMILES CN(C)CC1CCCN(CCCn2ccc(cc2=O)-c2ccn3c(cnc3c2)-c2ccccc2)C1 Show InChI InChI=1S/C29H35N5O/c1-31(2)21-23-8-6-13-32(22-23)14-7-15-33-16-11-26(19-29(33)35)25-12-17-34-27(20-30-28(34)18-25)24-9-4-3-5-10-24/h3-5,9-12,16-20,23H,6-8,13-15,21-22H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5306 (4-[(4-{3-phenylimidazo[1,2-a]pyridin-7-yl}phenyl)m...) Show SMILES NC(=O)N1CCN(Cc2ccc(cc2)-c2ccn3c(cnc3c2)-c2ccccc2)CC1 Show InChI InChI=1S/C25H25N5O/c26-25(31)29-14-12-28(13-15-29)18-19-6-8-20(9-7-19)22-10-11-30-23(17-27-24(30)16-22)21-4-2-1-3-5-21/h1-11,16-17H,12-15,18H2,(H2,26,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
RAC-beta serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373461 (CHEMBL259753) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2cccnc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-7-24(8-3-1)27-21-30-28(10-6-18-35-30)36-31(27)25-13-11-23(12-14-25)22-40-19-15-26(16-20-40)32-37-33(39-38-32)29-9-4-5-17-34-29/h1-14,17-18,21,26H,15-16,19-20,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt2				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5294 (3,6-diarylpyrazolo[1,5-a]pyrimidine 1 | 6-(4-metho...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccccc1 Show InChI InChI=1S/C19H15N3O/c1-23-17-9-7-14(8-10-17)16-11-20-19-18(12-21-22(19)13-16)15-5-3-2-4-6-15/h2-13H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373467 (CHEMBL261542) Show SMILES C(N1CCC(CC1)c1cc(n[nH]1)-c1ccncc1)c1ccc(cc1)-c1nc2ccccc2nc1-c1ccccc1 Show InChI InChI=1S/C34H30N6/c1-2-6-27(7-3-1)33-34(37-30-9-5-4-8-29(30)36-33)28-12-10-24(11-13-28)23-40-20-16-26(17-21-40)32-22-31(38-39-32)25-14-18-35-19-15-25/h1-15,18-19,22,26H,16-17,20-21,23H2,(H,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5304 (1-{4-[(4-{3-phenylimidazo[1,2-a]pyridin-7-yl}pheny...) Show SMILES CC(=O)N1CCN(Cc2ccc(cc2)-c2ccn3c(cnc3c2)-c2ccccc2)CC1 Show InChI InChI=1S/C26H26N4O/c1-20(31)29-15-13-28(14-16-29)19-21-7-9-22(10-8-21)24-11-12-30-25(18-27-26(30)17-24)23-5-3-2-4-6-23/h2-12,17-18H,13-16,19H2,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 14: 909-12 (2004) Article DOI: 10.1016/j.bmcl.2003.12.007 BindingDB Entry DOI: 10.7270/Q2JQ0Z63
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5388 (2,4-Disubstituted Pyrimidine 2l | N-[3,5-bis(trifl...) Show SMILES FC(F)(F)c1cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C21H13F6N5/c22-20(23,24)14-10-15(21(25,26)27)12-16(11-14)30-19-29-7-6-17(31-19)32-9-8-28-18(32)13-4-2-1-3-5-13/h1-12H,(H,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 13: 1673-7 (2003) Article DOI: 10.1016/s0960-894x(03)00244-0 BindingDB Entry DOI: 10.7270/Q2X0657G
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50373464 (CHEMBL260670) Show SMILES C(N1CCC(CC1)c1nnc([nH]1)-c1ccccn1)c1ccc(cc1)-c1nc2ncccc2cc1-c1ccccc1 Show InChI InChI=1S/C33H29N7/c1-2-7-24(8-3-1)28-21-27-9-6-18-35-31(27)36-30(28)25-13-11-23(12-14-25)22-40-19-15-26(16-20-40)32-37-33(39-38-32)29-10-4-5-17-34-29/h1-14,17-18,21,26H,15-16,19-20,22H2,(H,37,38,39)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Akt1 by cell-based assay				Bioorg Med Chem Lett 18: 3178-82 (2008) Article DOI: 10.1016/j.bmcl.2008.04.074 BindingDB Entry DOI: 10.7270/Q20V8DNR
					More data for this Ligand-Target Pair

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