| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-beta serine/threonine-protein kinase |
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| Ligand | BDBM50373465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_467868 (CHEMBL937418) |
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| IC50 | 83±n/a nM |
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| Citation |  Bilodeau, MT; Balitza, AE; Hoffman, JM; Manley, PJ; Barnett, SF; Defeo-Jones, D; Haskell, K; Jones, RE; Leander, K; Robinson, RG; Smith, AM; Huber, HE; Hartman, GD Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model. Bioorg Med Chem Lett18:3178-82 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-beta serine/threonine-protein kinase |
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| Name: | RAC-beta serine/threonine-protein kinase |
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| Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
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| Type: | Enzyme |
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| Mol. Mass.: | 55766.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 481 |
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| Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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| BDBM50373465 |
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| n/a |
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| Name | BDBM50373465 |
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| Synonyms: | CHEMBL260184 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H30N6O |
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| Mol. Mass. | 538.6416 |
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| SMILES | O=c1ccc(c[nH]1)-c1cc([nH]n1)C1CCN(Cc2ccc(cc2)-c2nc3ncccc3cc2-c2ccccc2)CC1 |
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| Structure | 
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