Reaction Details |
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Target | Transketolase |
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Ligand | BDBM50230596 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_468404 (CHEMBL934304) |
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Kd | 29±n/a nM |
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Citation | Thomas, AA; Le Huerou, Y; De Meese, J; Gunawardana, I; Kaplan, T; Romoff, TT; Gonzales, SS; Condroski, K; Boyd, SA; Ballard, J; Bernat, B; DeWolf, W; Han, M; Lee, P; Lemieux, C; Pedersen, R; Pheneger, J; Poch, G; Smith, D; Sullivan, F; Weiler, S; Wright, SK; Lin, J; Brandhuber, B; Vigers, G Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett18:2206-10 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transketolase |
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Name: | Transketolase |
Synonyms: | TK | TKT | TKT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 67886.43 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_468615 |
Residue: | 623 |
Sequence: | MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
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BDBM50230596 |
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n/a |
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Name | BDBM50230596 |
Synonyms: | 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-thiazol-3-ium; chloride | CHEMBL252842 | CHEMBL256454 |
Type | Small organic molecule |
Emp. Form. | C12H16N3OS |
Mol. Mass. | 250.339 |
SMILES | Cc1ccc(C[n+]2csc(CCO)c2)c(N)n1 |
Structure |
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