| Reaction Details |
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 | Report a problem with these data |
| Target | Transketolase |
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| Ligand | BDBM50373744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468405 (CHEMBL934305) |
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| EC50 | 2300±n/a nM |
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| Citation |  Thomas, AA; Le Huerou, Y; De Meese, J; Gunawardana, I; Kaplan, T; Romoff, TT; Gonzales, SS; Condroski, K; Boyd, SA; Ballard, J; Bernat, B; DeWolf, W; Han, M; Lee, P; Lemieux, C; Pedersen, R; Pheneger, J; Poch, G; Smith, D; Sullivan, F; Weiler, S; Wright, SK; Lin, J; Brandhuber, B; Vigers, G Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett18:2206-10 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transketolase |
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| Name: | Transketolase |
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| Synonyms: | TK | TKT | TKT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67886.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_468615 |
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| Residue: | 623 |
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| Sequence: | MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
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| BDBM50373744 |
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| n/a |
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| Name | BDBM50373744 |
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| Synonyms: | CHEMBL257883 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20N3O2S |
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| Mol. Mass. | 306.403 |
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| SMILES | COC(=O)CCc1sc[n+](Cc2ccc(C)nc2N)c1C |
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| Structure | 
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