| Reaction Details |
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 | Report a problem with these data |
| Target | Transketolase |
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| Ligand | BDBM50373878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_468614 (CHEMBL947911) |
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| Kd | 16±n/a nM |
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| Citation |  Thomas, AA; De Meese, J; Le Huerou, Y; Boyd, SA; Romoff, TT; Gonzales, SS; Gunawardana, I; Kaplan, T; Sullivan, F; Condroski, K; Lyssikatos, JP; Aicher, TD; Ballard, J; Bernat, B; DeWolf, W; Han, M; Lemieux, C; Smith, D; Weiler, S; Wright, SK; Vigers, G; Brandhuber, B Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett18:509-12 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transketolase |
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| Name: | Transketolase |
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| Synonyms: | TK | TKT | TKT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67886.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_468615 |
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| Residue: | 623 |
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| Sequence: | MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
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| BDBM50373878 |
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| n/a |
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| Name | BDBM50373878 |
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| Synonyms: | CHEMBL403021 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N4O8P2S |
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| Mol. Mass. | 440.306 |
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| SMILES | Cc1c(CCO[P@](O)(=O)OP(O)(O)=O)sc(=O)n1Cc1cnc(C)nc1N |r| |
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| Structure | 
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