Reaction Details |
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Target | Transketolase |
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Ligand | BDBM50373879 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_468614 (CHEMBL947911) |
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Kd | 170±n/a nM |
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Citation | Thomas, AA; De Meese, J; Le Huerou, Y; Boyd, SA; Romoff, TT; Gonzales, SS; Gunawardana, I; Kaplan, T; Sullivan, F; Condroski, K; Lyssikatos, JP; Aicher, TD; Ballard, J; Bernat, B; DeWolf, W; Han, M; Lemieux, C; Smith, D; Weiler, S; Wright, SK; Vigers, G; Brandhuber, B Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett18:509-12 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transketolase |
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Name: | Transketolase |
Synonyms: | TK | TKT | TKT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 67886.43 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_468615 |
Residue: | 623 |
Sequence: | MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV
ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA
ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA
KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN
IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI
ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS
IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII
YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL
DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE
LLKMFGIDRDAIAQAVRGLITKA
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BDBM50373879 |
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n/a |
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Name | BDBM50373879 |
Synonyms: | CHEMBL430409 |
Type | Small organic molecule |
Emp. Form. | C13H21N4O6P2S |
Mol. Mass. | 423.341 |
SMILES | Cc1c(CCOP(C)(=O)OP(O)(O)=O)sc[n+]1Cc1cnc(C)nc1N |
Structure |
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