| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50374176 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_469022 (CHEMBL949333) |
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| IC50 | >20000±n/a nM |
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| Citation |  Costanzo, MJ; Yabut, SC; Zhang, HC; White, KB; de Garavilla, L; Wang, Y; Minor, LK; Tounge, BA; Barnakov, AN; Lewandowski, F; Milligan, C; Spurlino, JC; Abraham, WM; Boswell-Smith, V; Page, CP; Maryanoff, BE Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett18:2114-21 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50374176 |
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| n/a |
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| Name | BDBM50374176 |
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| Synonyms: | CHEMBL255590 | JNJ-27390467 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N2O3 |
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| Mol. Mass. | 412.4804 |
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| SMILES | NCc1ccc2OCC3(CCN(CC3)C(=O)c3ccc(o3)C#Cc3ccccc3)c2c1 |
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| Structure | 
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