| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase SYK |
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| Ligand | BDBM50375355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_471541 (CHEMBL938476) |
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| IC50 | >10000±n/a nM |
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| Citation |  Mukaiyama, H; Nishimura, T; Kobayashi, S; Komatsu, Y; Kikuchi, S; Ozawa, T; Kamada, N; Ohnota, H Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade. Bioorg Med Chem16:909-21 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase SYK |
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| Name: | Tyrosine-protein kinase SYK |
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| Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
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| Type: | Enzyme |
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| Mol. Mass.: | 72079.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43405 |
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| Residue: | 635 |
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| Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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| BDBM50375355 |
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| n/a |
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| Name | BDBM50375355 |
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| Synonyms: | CHEMBL260861 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H30N6O4 |
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| Mol. Mass. | 502.5649 |
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| SMILES | COc1cc(Nc2nn3c(N[C@H](CO)Cc4ccccc4)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 |
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| Structure | 
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