Found 334 hits with Last Name = 'kamada' and Initial = 'n' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375355
(CHEMBL260861)Show SMILES COc1cc(Nc2nn3c(N[C@H](CO)Cc4ccccc4)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 Show InChI InChI=1S/C27H30N6O4/c1-36-20-11-18(12-21(13-20)37-2)30-26-24(25(28)35)27-31-22(17-8-9-17)14-23(33(27)32-26)29-19(15-34)10-16-6-4-3-5-7-16/h3-7,11-14,17,19,29,34H,8-10,15H2,1-2H3,(H2,28,35)(H,30,32)/t19-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559528
(CHEMBL3950588)Show SMILES CCc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559538
(CHEMBL3908950)Show SMILES CSc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375361
(CHEMBL260157)Show SMILES COc1cc(Nc2nn3c(N[C@H](CO)Cc4c[nH]c5ccccc45)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 Show InChI InChI=1S/C29H31N7O4/c1-39-20-10-18(11-21(12-20)40-2)33-28-26(27(30)38)29-34-24(16-7-8-16)13-25(36(29)35-28)32-19(15-37)9-17-14-31-23-6-4-3-5-22(17)23/h3-6,10-14,16,19,31-32,37H,7-9,15H2,1-2H3,(H2,30,38)(H,33,35)/t19-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375360
(CHEMBL261188)Show SMILES COc1cc(Nc2nn3c(N[C@H](CO)Cc4cccnc4)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 Show InChI InChI=1S/C26H29N7O4/c1-36-19-9-17(10-20(11-19)37-2)30-25-23(24(27)35)26-31-21(16-5-6-16)12-22(33(26)32-25)29-18(14-34)8-15-4-3-7-28-13-15/h3-4,7,9-13,16,18,29,34H,5-6,8,14H2,1-2H3,(H2,27,35)(H,30,32)/t18-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50394556
(CHEMBL2159100)Show SMILES OC[C@H]1O[C@@H](Oc2[nH]nc(c2Cc2ccc(OCc3ccccc3)cc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C24H25F3N2O7/c25-24(26,27)21-16(10-13-6-8-15(9-7-13)34-12-14-4-2-1-3-5-14)22(29-28-21)36-23-20(33)19(32)18(31)17(11-30)35-23/h1-9,17-20,23,30-33H,10-12H2,(H,28,29)/t17-,18-,19+,20-,23+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50375355
(CHEMBL260861)Show SMILES COc1cc(Nc2nn3c(N[C@H](CO)Cc4ccccc4)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 Show InChI InChI=1S/C27H30N6O4/c1-36-20-11-18(12-21(13-20)37-2)30-26-24(25(28)35)27-31-22(17-8-9-17)14-23(33(27)32-26)29-19(15-34)10-16-6-4-3-5-7-16/h3-7,11-14,17,19,29,34H,8-10,15H2,1-2H3,(H2,28,35)(H,30,32)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Lck |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50426906
(CHEMBL2323692)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)CO)cc1 |r| Show InChI InChI=1S/C27H41N3O8/c1-15(2)21-18(25(30-29-21)38-26-24(36)23(35)22(34)19(13-31)37-26)12-17-10-8-16(9-11-17)6-5-7-20(33)28-27(3,4)14-32/h8-11,15,19,22-24,26,31-32,34-36H,5-7,12-14H2,1-4H3,(H,28,33)(H,29,30)/t19-,22-,23+,24-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375366
(CHEMBL406418)Show SMILES COc1cc(Nc2nn3c(N[C@@H](CO)C(C)C)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 Show InChI InChI=1S/C23H30N6O4/c1-12(2)18(11-30)26-19-10-17(13-5-6-13)27-23-20(21(24)31)22(28-29(19)23)25-14-7-15(32-3)9-16(8-14)33-4/h7-10,12-13,18,26,30H,5-6,11H2,1-4H3,(H2,24,31)(H,25,28)/t18-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50198353
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1 Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of Lck |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559527
(CHEMBL3907970)Show SMILES CCCc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375364
(CHEMBL261743)Show SMILES COc1cc(Nc2nn3c(cc(nc3c2C(N)=O)C2CC2)N2CCC[C@@H]2CO)cc(OC)c1 Show InChI InChI=1S/C23H28N6O4/c1-32-16-8-14(9-17(10-16)33-2)25-22-20(21(24)31)23-26-18(13-5-6-13)11-19(29(23)27-22)28-7-3-4-15(28)12-30/h8-11,13,15,30H,3-7,12H2,1-2H3,(H2,24,31)(H,25,27)/t15-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50426894
(CHEMBL2323684)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCN(C)CC2)cc1 |r| Show InChI InChI=1S/C32H49N5O8/c1-19(2)25-22(29(35-34-25)45-30-28(42)27(41)26(40)23(18-38)44-30)17-21-11-9-20(10-12-21)7-6-8-24(39)33-32(3,4)31(43)37-15-13-36(5)14-16-37/h9-12,19,23,26-28,30,38,40-42H,6-8,13-18H2,1-5H3,(H,33,39)(H,34,35)/t23-,26-,27+,28-,30+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559522
(CHEMBL3960449)Show SMILES CC(C)Oc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198360
(CHEMBL227906 | N-(2,6-dimethylphenyl)-5-(3-methoxy...)Show InChI InChI=1S/C21H20N4O/c1-14-6-4-7-15(2)20(14)24-21-19-11-22-13-25(19)18(12-23-21)16-8-5-9-17(10-16)26-3/h4-13H,1-3H3,(H,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50426887
(CHEMBL2323695)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1C |r| Show InChI InChI=1S/C32H49N5O8/c1-18(2)25-22(29(36-35-25)45-30-28(42)27(41)26(40)23(17-38)44-30)16-21-10-9-20(15-19(21)3)7-6-8-24(39)34-32(4,5)31(43)37-13-11-33-12-14-37/h9-10,15,18,23,26-28,30,33,38,40-42H,6-8,11-14,16-17H2,1-5H3,(H,34,39)(H,35,36)/t23-,26-,27+,28-,30+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559524
(CHEMBL3923809)Show SMILES CCOc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559525
(CHEMBL3934976)Show SMILES COc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375362
(CHEMBL260860)Show SMILES COc1cc(Nc2nn3c(N[C@@H](CO)Cc4ccccc4)cc(nc3c2C(N)=O)C2CC2)cc(OC)c1 Show InChI InChI=1S/C27H30N6O4/c1-36-20-11-18(12-21(13-20)37-2)30-26-24(25(28)35)27-31-22(17-8-9-17)14-23(33(27)32-26)29-19(15-34)10-16-6-4-3-5-7-16/h3-7,11-14,17,19,29,34H,8-10,15H2,1-2H3,(H2,28,35)(H,30,32)/t19-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559529
(CHEMBL3896936)Show SMILES Cc1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(C)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50426906
(CHEMBL2323692)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)CO)cc1 |r| Show InChI InChI=1S/C27H41N3O8/c1-15(2)21-18(25(30-29-21)38-26-24(36)23(35)22(34)19(13-31)37-26)12-17-10-8-16(9-11-17)6-5-7-20(33)28-27(3,4)14-32/h8-11,15,19,22-24,26,31-32,34-36H,5-7,12-14H2,1-4H3,(H,28,33)(H,29,30)/t19-,22-,23+,24-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
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| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198372
(CHEMBL387641 | N-(2,6-dimethylphenyl)-5-thiophen-2...)Show InChI InChI=1S/C18H16N4S/c1-12-5-3-6-13(2)17(12)21-18-15-9-19-11-22(15)14(10-20-18)16-7-4-8-23-16/h3-11H,1-2H3,(H,20,21) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198370
(CHEMBL223873 | N-(2,6-dimethyl-phenyl)-5-phenylimi...)Show InChI InChI=1S/C20H18N4/c1-14-7-6-8-15(2)19(14)23-20-18-11-21-13-24(18)17(12-22-20)16-9-4-3-5-10-16/h3-13H,1-2H3,(H,22,23) | PDB
MMDB
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B.MOAD
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| CHEMBL
DrugBank
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UniChem
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| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559523
(CHEMBL3915296)Show SMILES CCCOc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
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| KEGG
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PC sid
UniChem
| Article
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50426895
(CHEMBL2323683)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1 |r| Show InChI InChI=1S/C31H47N5O8/c1-18(2)24-21(28(35-34-24)44-29-27(41)26(40)25(39)22(17-37)43-29)16-20-10-8-19(9-11-20)6-5-7-23(38)33-31(3,4)30(42)36-14-12-32-13-15-36/h8-11,18,22,25-27,29,32,37,39-41H,5-7,12-17H2,1-4H3,(H,33,38)(H,34,35)/t22-,25-,26+,27-,29+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198361
(CHEMBL227699 | N-(2,6-dimethylphenyl)-5-[4-(2-pyrr...)Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(OCCN3CCCC3)cc2)n2cncc12 Show InChI InChI=1S/C26H29N5O/c1-19-6-5-7-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-8-10-22(11-9-21)32-15-14-30-12-3-4-13-30/h5-11,16-18H,3-4,12-15H2,1-2H3,(H,28,29) | PDB
MMDB
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antibodypedia
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198378
(CHEMBL389031 | N-(2,6-dimethylphenyl)-5-(4-methoxy...)Show InChI InChI=1S/C21H20N4O/c1-14-5-4-6-15(2)20(14)24-21-19-11-22-13-25(19)18(12-23-21)16-7-9-17(26-3)10-8-16/h4-13H,1-3H3,(H,23,24) | PDB
MMDB
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B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559526
(CHEMBL3969998)Show SMILES CC(C)c1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
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UniChem
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559539
(CHEMBL3980689)Show SMILES CSc1ccc(Cc2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)n[nH]c2C(F)(F)F)cc1 |r| | PDB
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antibodypedia
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559517
(Remogliflozin | Remogliflozin a)Show SMILES CC(C)Oc1ccc(Cc2c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)nn(C(C)C)c2C)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
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MCE
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UniChem
| Article
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50426894
(CHEMBL2323684)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCN(C)CC2)cc1 |r| Show InChI InChI=1S/C32H49N5O8/c1-19(2)25-22(29(35-34-25)45-30-28(42)27(41)26(40)23(18-38)44-30)17-21-11-9-20(10-12-21)7-6-8-24(39)33-32(3,4)31(43)37-15-13-36(5)14-16-37/h9-12,19,23,26-28,30,38,40-42H,6-8,13-18H2,1-5H3,(H,33,39)(H,34,35)/t23-,26-,27+,28-,30+/m1/s1 | PDB
UniProtKB/SwissProt
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| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198365
(CHEMBL226613 | N-[5-(4-dimethylaminophenyl)imidazo...)Show SMILES CN(C)c1ccc(cc1)-c1cnc(Nc2c(C)cccc2C)c2cncn12 Show InChI InChI=1S/C22H23N5/c1-15-6-5-7-16(2)21(15)25-22-20-12-23-14-27(20)19(13-24-22)17-8-10-18(11-9-17)26(3)4/h5-14H,1-4H3,(H,24,25) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198377
(CHEMBL389422 | N-(2,6-dimethylphenyl)-5-[3-(1-meth...)Show SMILES CN1CCCC(COc2cccc(c2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1 Show InChI InChI=1S/C27H31N5O/c1-19-7-4-8-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-10-5-11-23(13-22)33-17-21-9-6-12-31(3)16-21/h4-5,7-8,10-11,13-15,18,21H,6,9,12,16-17H2,1-3H3,(H,29,30) | PDB
MMDB
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B.MOAD
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antibodypedia
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198353
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1 Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
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PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50426895
(CHEMBL2323683)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1 |r| Show InChI InChI=1S/C31H47N5O8/c1-18(2)24-21(28(35-34-24)44-29-27(41)26(40)25(39)22(17-37)43-29)16-20-10-8-19(9-11-20)6-5-7-23(38)33-31(3,4)30(42)36-14-12-32-13-15-36/h8-11,18,22,25-27,29,32,37,39-41H,5-7,12-17H2,1-4H3,(H,33,38)(H,34,35)/t22-,25-,26+,27-,29+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198353
(CHEMBL227753 | CHEMBL534948 | N-(2,6-dimethylpheny...)Show SMILES CN1CCCC(COc2ccc(cc2)-c2cnc(Nc3c(C)cccc3C)c3cncn23)C1 Show InChI InChI=1S/C27H31N5O/c1-19-6-4-7-20(2)26(19)30-27-25-14-28-18-32(25)24(15-29-27)22-9-11-23(12-10-22)33-17-21-8-5-13-31(3)16-21/h4,6-7,9-12,14-15,18,21H,5,8,13,16-17H2,1-3H3,(H,29,30) | PDB
MMDB
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B.MOAD
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Rattus norvegicus) | BDBM50426887
(CHEMBL2323695)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCNCC2)cc1C |r| Show InChI InChI=1S/C32H49N5O8/c1-18(2)25-22(29(36-35-25)45-30-28(42)27(41)26(40)23(17-38)44-30)16-21-10-9-20(15-19(21)3)7-6-8-24(39)34-32(4,5)31(43)37-13-11-33-12-14-37/h9-10,15,18,23,26-28,30,33,38,40-42H,6-8,11-14,16-17H2,1-5H3,(H,34,39)(H,35,36)/t23-,26-,27+,28-,30+/m1/s1 | PDB
Reactome pathway
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of rat SGLT1 |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198354
(CHEMBL389451 | N-[5-(3,4-dimethoxyphenyl)imidazo[1...)Show SMILES COc1ccc(cc1OC)-c1cnc(Nc2c(C)cccc2C)c2cncn12 Show InChI InChI=1S/C22H22N4O2/c1-14-6-5-7-15(2)21(14)25-22-18-11-23-13-26(18)17(12-24-22)16-8-9-19(27-3)20(10-16)28-4/h5-13H,1-4H3,(H,24,25) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50426889
(CHEMBL2323409)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)NCCN(C)C)cc1 |r| Show InChI InChI=1S/C31H49N5O8/c1-18(2)24-21(28(35-34-24)44-29-27(41)26(40)25(39)22(17-37)43-29)16-20-12-10-19(11-13-20)8-7-9-23(38)33-31(3,4)30(42)32-14-15-36(5)6/h10-13,18,22,25-27,29,37,39-41H,7-9,14-17H2,1-6H3,(H,32,42)(H,33,38)(H,34,35)/t22-,25-,26+,27-,29+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375363
(CHEMBL261744)Show SMILES COc1cc(Nc2nn3c(cc(nc3c2C(N)=O)C2CC2)N2CCC[C@H]2CO)cc(OC)c1 Show InChI InChI=1S/C23H28N6O4/c1-32-16-8-14(9-17(10-16)33-2)25-22-20(21(24)31)23-26-18(13-5-6-13)11-19(29(23)27-22)28-7-3-4-15(28)12-30/h8-11,13,15,30H,3-7,12H2,1-2H3,(H2,24,31)(H,25,27)/t15-/m0/s1 | PDB
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50426893
(CHEMBL2323405)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCCCC2)cc1 |r| Show InChI InChI=1S/C32H48N4O8/c1-19(2)25-22(29(35-34-25)44-30-28(41)27(40)26(39)23(18-37)43-30)17-21-13-11-20(12-14-21)9-8-10-24(38)33-32(3,4)31(42)36-15-6-5-7-16-36/h11-14,19,23,26-28,30,37,39-41H,5-10,15-18H2,1-4H3,(H,33,38)(H,34,35)/t23-,26-,27+,28-,30+/m1/s1 | PDB
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 1
(Homo sapiens (Human)) | BDBM50394532
(CHEMBL2159094)Show SMILES OC[C@H]1O[C@@H](Oc2[nH]nc(c2Cc2ccccc2OCc2ccccc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C24H25F3N2O7/c25-24(26,27)21-15(10-14-8-4-5-9-16(14)34-12-13-6-2-1-3-7-13)22(29-28-21)36-23-20(33)19(32)18(31)17(11-30)35-23/h1-9,17-20,23,30-33H,10-12H2,(H,28,29)/t17-,18-,19+,20-,23+/m1/s1 | PDB
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198379
(CHEMBL227836 | N-(2,6-dimethylphenyl)-5-[4-(2-morp...)Show SMILES Cc1cccc(C)c1Nc1ncc(-c2ccc(OCCN3CCOCC3)cc2)n2cncc12 Show InChI InChI=1S/C26H29N5O2/c1-19-4-3-5-20(2)25(19)29-26-24-16-27-18-31(24)23(17-28-26)21-6-8-22(9-7-21)33-15-12-30-10-13-32-14-11-30/h3-9,16-18H,10-15H2,1-2H3,(H,28,29) | PDB
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| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198369
(CHEMBL388859 | N-(5-phenylimidazo[1,5-a]pyrazin-8-...)Show InChI InChI=1S/C21H20N4/c1-14-9-15(2)20(16(3)10-14)24-21-19-11-22-13-25(19)18(12-23-21)17-7-5-4-6-8-17/h4-13H,1-3H3,(H,23,24) | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM20875
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1 | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake |
Bioorg Med Chem 20: 6598-612 (2012)
Article DOI: 10.1016/j.bmc.2012.09.037
BindingDB Entry DOI: 10.7270/Q26D5V36 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50375367
(CHEMBL405893)Show SMILES COc1cc(Nc2nn3c(N[C@@H](CO)C(C)C)cc(nc3c2C(N)=O)C(C)C)cc(OC)c1 Show InChI InChI=1S/C23H32N6O4/c1-12(2)17-10-19(26-18(11-30)13(3)4)29-23(27-17)20(21(24)31)22(28-29)25-14-7-15(32-5)9-16(8-14)33-6/h7-10,12-13,18,26,30H,11H2,1-6H3,(H2,24,31)(H,25,28)/t18-/m0/s1 | PDB
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PC cid
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human cSrc |
Bioorg Med Chem 16: 909-21 (2008)
Article DOI: 10.1016/j.bmc.2007.10.068
BindingDB Entry DOI: 10.7270/Q2CF9R01 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198366
(CHEMBL223912 | N-(2,6-dichlorophenyl)-5-phenylimid...)Show InChI InChI=1S/C18H12Cl2N4/c19-13-7-4-8-14(20)17(13)23-18-16-9-21-11-24(16)15(10-22-18)12-5-2-1-3-6-12/h1-11H,(H,22,23) | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50426893
(CHEMBL2323405)Show SMILES CC(C)c1n[nH]c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(CCCC(=O)NC(C)(C)C(=O)N2CCCCC2)cc1 |r| Show InChI InChI=1S/C32H48N4O8/c1-19(2)25-22(29(35-34-25)44-30-28(41)27(40)26(39)23(18-37)43-30)17-21-13-11-20(12-14-21)9-8-10-24(38)33-32(3,4)31(42)36-15-6-5-7-16-36/h11-14,19,23,26-28,30,37,39-41H,5-10,15-18H2,1-4H3,(H,33,38)(H,34,35)/t23-,26-,27+,28-,30+/m1/s1 | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake |
Bioorg Med Chem 21: 748-65 (2013)
Article DOI: 10.1016/j.bmc.2012.11.041
BindingDB Entry DOI: 10.7270/Q2445NS9 |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50198357
(CHEMBL228091 | N-(2,6-dimethylphenyl)-5-(4-fluorop...)Show InChI InChI=1S/C20H17FN4/c1-13-4-3-5-14(2)19(13)24-20-18-10-22-12-25(18)17(11-23-20)15-6-8-16(21)9-7-15/h3-12H,1-2H3,(H,23,24) | PDB
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PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Kissei Pharmaceutical Company Ltd
Curated by ChEMBL
| Assay Description
Inhibition of cSrc by coupled spectrophotometric enzyme assay |
Bioorg Med Chem 15: 868-85 (2006)
Article DOI: 10.1016/j.bmc.2006.10.041
BindingDB Entry DOI: 10.7270/Q2DZ094H |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559519
(CHEMBL4786882)Show SMILES CCn1nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(Cc2ccc(OC(C)C)cc2)c1C |r| | PDB
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TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
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