| Reaction Details |
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 | Report a problem with these data |
| Target | Cytosolic phospholipase A2 |
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| Ligand | BDBM50059523 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_475609 (CHEMBL923242) |
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| IC50 | 2300±n/a nM |
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| Citation |  Fritsche, A; Elfringhoff, AS; Fabian, J; Lehr, M 1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility. Bioorg Med Chem16:3489-500 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytosolic phospholipase A2 |
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| Name: | Cytosolic phospholipase A2 |
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| Synonyms: | CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA |
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| Type: | Protein |
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| Mol. Mass.: | 85219.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P47712 |
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| Residue: | 749 |
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| Sequence: | MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEV
PFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEG
LHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEE
LENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETE
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRR
QNPSRCSVSLSNVEARRFFNKEFLSKPKA
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| BDBM50059523 |
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| n/a |
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| Name | BDBM50059523 |
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| Synonyms: | (6Z,9Z,12Z,15Z)-1,1,1-trifluorohenicosa-6,9,12,15-tetraen-2-one | AACOCF3 | Arachidonic acid trifluoromethyl ketone | Arachidonyl trifluoromethyl ketone | Arachidonyltrifluoromethane | CHEMBL281211 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H31F3O |
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| Mol. Mass. | 356.4654 |
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| SMILES | CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F |
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| Structure | 
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