Found 156 hits with Last Name = 'elfringhoff' and Initial = 'as' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185354
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34) | PDB
MMDB
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185348
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185354
(3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopro...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C30H37NO7/c1-3-4-5-6-7-8-9-10-17-37-24-12-14-25(15-13-24)38-21-23(32)19-31-20-27(30(35)36-2)26-18-22(29(33)34)11-16-28(26)31/h11-16,18,20H,3-10,17,19,21H2,1-2H3,(H,33,34) | PDB
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CHEMBL
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185348
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277800
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-5-c...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-12-23(13-10-19)31-18-22(28)17-27-24-14-11-20(25(29)30)15-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release |
Bioorg Med Chem Lett 19: 2107-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277800
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-5-c...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-12-23(13-10-19)31-18-22(28)17-27-24-14-11-20(25(29)30)15-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185348
(3-(methoxycarbonyl)-1-(3-(4-octylphenoxy)-2-oxopro...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H33NO6/c1-3-4-5-6-7-8-9-20-10-13-23(14-11-20)35-19-22(30)17-29-18-25(28(33)34-2)24-16-21(27(31)32)12-15-26(24)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,31,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185351
(3-acetyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H33NO5/c1-3-4-5-6-7-8-9-21-10-13-24(14-11-21)34-19-23(31)17-29-18-26(20(2)30)25-16-22(28(32)33)12-15-27(25)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,32,33) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185350
(1-(3-(4-(decyloxy)phenoxy)-2-oxopropyl)-1H-indole-...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H35NO5/c1-2-3-4-5-6-7-8-9-18-33-25-11-13-26(14-12-25)34-21-24(30)20-29-17-16-22-19-23(28(31)32)10-15-27(22)29/h10-17,19H,2-9,18,20-21H2,1H3,(H,31,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50161518
(1-(oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one...)Show InChI InChI=1S/C18H18N2O2/c21-15(18-20-17-16(22-18)12-7-13-19-17)11-6-2-5-10-14-8-3-1-4-9-14/h1,3-4,7-9,12-13H,2,5-6,10-11H2 | PDB
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PC cid
PC sid
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of FAAH from rat brain microsomes by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185349
(3-formyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C27H31NO5/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)17-28-16-22(18-29)25-15-21(27(31)32)11-14-26(25)28/h9-16,18H,2-8,17,19H2,1H3,(H,31,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233835
(CHEMBL4097068)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)C(C)C)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C30H37NO5/c1-4-5-6-7-8-9-10-22-11-14-25(15-12-22)36-20-24(32)18-31-19-27(29(33)21(2)3)26-17-23(30(34)35)13-16-28(26)31/h11-17,19,21H,4-10,18,20H2,1-3H3,(H,34,35) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233832
(CHEMBL1800991)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C30H37NO5/c1-3-5-6-7-8-9-11-22-12-15-25(16-13-22)36-21-24(32)19-31-20-27(29(33)10-4-2)26-18-23(30(34)35)14-17-28(26)31/h12-18,20H,3-11,19,21H2,1-2H3,(H,34,35) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50110846
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29) | PDB
MMDB
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UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release |
Bioorg Med Chem Lett 19: 2107-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50110846
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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DrugBank
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185345
(3-cyano-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indo...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C#N)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C27H30N2O4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)18-29-17-22(16-28)25-15-21(27(31)32)11-14-26(25)29/h9-15,17H,2-8,18-19H2,1H3,(H,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50110846
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50110846
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233833
(CHEMBL1085637)Show SMILES CC(C)C(=O)c1cn(CC(=O)COc2ccc(Oc3ccccc3)cc2)c2ccc(cc12)C(O)=O Show InChI InChI=1S/C28H25NO6/c1-18(2)27(31)25-16-29(26-13-8-19(28(32)33)14-24(25)26)15-20(30)17-34-21-9-11-23(12-10-21)35-22-6-4-3-5-7-22/h3-14,16,18H,15,17H2,1-2H3,(H,32,33) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185351
(3-acetyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H33NO5/c1-3-4-5-6-7-8-9-21-10-13-24(14-11-21)34-19-23(31)17-29-18-26(20(2)30)25-16-22(28(32)33)12-15-27(25)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,32,33) | PDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233834
(CHEMBL4079052)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCOC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C31H39NO6/c1-3-4-5-6-7-8-10-23-12-15-26(16-13-23)38-22-25(33)20-32-21-28(30(34)11-9-18-37-2)27-19-24(31(35)36)14-17-29(27)32/h12-17,19,21H,3-11,18,20,22H2,1-2H3,(H,35,36) | PDB
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University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185345
(3-cyano-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indo...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C#N)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C27H30N2O4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)18-29-17-22(16-28)25-15-21(27(31)32)11-14-26(25)29/h9-15,17H,2-8,18-19H2,1H3,(H,31,32) | PDB
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University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185345
(3-cyano-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indo...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C#N)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C27H30N2O4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)18-29-17-22(16-28)25-15-21(27(31)32)11-14-26(25)29/h9-15,17H,2-8,18-19H2,1H3,(H,31,32) | PDB
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185349
(3-formyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C27H31NO5/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)17-28-16-22(18-29)25-15-21(27(31)32)11-14-26(25)28/h9-16,18H,2-8,17,19H2,1H3,(H,31,32) | PDB
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University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185351
(3-acetyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H33NO5/c1-3-4-5-6-7-8-9-21-10-13-24(14-11-21)34-19-23(31)17-29-18-26(20(2)30)25-16-22(28(32)33)12-15-27(25)29/h10-16,18H,3-9,17,19H2,1-2H3,(H,32,33) | PDB
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University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185349
(3-formyl-1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-ind...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C27H31NO5/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)33-19-23(30)17-28-16-22(18-29)25-15-21(27(31)32)11-14-26(25)28/h9-16,18H,2-8,17,19H2,1H3,(H,31,32) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277799
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d][1,2...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2nnc3ccc(cc23)C(O)=O)cc1 Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-5-6-7-8-18-9-12-21(13-10-18)31-17-20(28)16-27-23-15-19(24(29)30)11-14-22(23)25-26-27/h9-15H,2-8,16-17H2,1H3,(H,29,30) | PDB
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University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277799
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d][1,2...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2nnc3ccc(cc23)C(O)=O)cc1 Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-5-6-7-8-18-9-12-21(13-10-18)31-17-20(28)16-27-23-15-19(24(29)30)11-14-22(23)25-26-27/h9-15H,2-8,16-17H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release |
Bioorg Med Chem Lett 19: 2107-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha in TPA-stimulated intact human platelets assessed as liberation of arachidonic acid after 60 mins |
Bioorg Med Chem 16: 3489-500 (2008)
Article DOI: 10.1016/j.bmc.2008.02.019
BindingDB Entry DOI: 10.7270/Q2W66MN0 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2-alpha activity assessed by TPA-induced arachidonic acid release in human platelet |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185350
(1-(3-(4-(decyloxy)phenoxy)-2-oxopropyl)-1H-indole-...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C28H35NO5/c1-2-3-4-5-6-7-8-9-18-33-25-11-13-26(14-12-25)34-21-24(30)20-29-17-16-22-19-23(28(31)32)10-15-27(22)29/h10-17,19H,2-9,18,20-21H2,1H3,(H,31,32) | PDB
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University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233829
(CHEMBL1801026)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC(O)=O)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C32H39NO7/c1-2-3-4-5-6-7-10-23-13-16-26(17-14-23)40-22-25(34)20-33-21-28(30(35)11-8-9-12-31(36)37)27-19-24(32(38)39)15-18-29(27)33/h13-19,21H,2-12,20,22H2,1H3,(H,36,37)(H,38,39) | PDB
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University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233837
(CHEMBL4086908)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCO)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C30H37NO6/c1-2-3-4-5-6-7-9-22-11-14-25(15-12-22)37-21-24(33)19-31-20-27(29(34)10-8-17-32)26-18-23(30(35)36)13-16-28(26)31/h11-16,18,20,32H,2-10,17,19,21H2,1H3,(H,35,36) | PDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50132713
(Arachidonic acid derivative | CHEMBL113262 | Methy...)Show InChI InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16- | PDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of FAAH from rat brain microsomes by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277833
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-6-c...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3ccc(cc23)C(O)=O)cc1 Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-13-23(14-10-19)31-18-22(28)17-27-24-15-20(25(29)30)11-12-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277798
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d][1,2...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2nnc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-5-6-7-8-18-9-12-21(13-10-18)31-17-20(28)16-27-23-14-11-19(24(29)30)15-22(23)25-26-27/h9-15H,2-8,16-17H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release |
Bioorg Med Chem Lett 19: 2107-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277833
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indazole-6-c...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ncc3ccc(cc23)C(O)=O)cc1 Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-13-23(14-10-19)31-18-22(28)17-27-24-15-20(25(29)30)11-12-21(24)16-26-27/h9-16H,2-8,17-18H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release |
Bioorg Med Chem Lett 19: 2107-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277798
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d][1,2...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2nnc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C24H29N3O4/c1-2-3-4-5-6-7-8-18-9-12-21(13-10-18)31-17-20(28)16-27-23-14-11-19(24(29)30)15-22(23)25-26-27/h9-15H,2-8,16-17H2,1H3,(H,29,30) | PDB
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PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50085993
((E)-N-(((2S,4R)-4-((biphenyl-2-ylmethyl)(isobutyl)...)Show SMILES CC(C)CN(Cc1ccccc1-c1ccccc1)[C@@H]1C[C@@H](CNC(=O)C=Cc2ccc(C=C3SC(O)=NC3=O)cc2)N(C1)C(=O)c1ccccc1C(=O)c1ccc(F)cc1F |w:31.32,26.28,c:37| Show InChI InChI=1S/C49H44F2N4O5S/c1-31(2)28-54(29-35-12-6-7-13-39(35)34-10-4-3-5-11-34)38-26-37(27-52-45(56)23-20-32-16-18-33(19-17-32)24-44-47(58)53-49(60)61-44)55(30-38)48(59)41-15-9-8-14-40(41)46(57)42-22-21-36(50)25-43(42)51/h3-25,31,37-38H,26-30H2,1-2H3,(H,52,56)(H,53,58,60)/t37-,38+/m0/s1 | PDB
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233830
(CHEMBL4067166)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCO)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C32H41NO6/c1-2-3-4-5-6-8-11-24-13-16-27(17-14-24)39-23-26(35)21-33-22-29(31(36)12-9-7-10-19-34)28-20-25(32(37)38)15-18-30(28)33/h13-18,20,22,34H,2-12,19,21,23H2,1H3,(H,37,38) | PDB
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 in human platelets assessed as arachidonic acid release |
Bioorg Med Chem Lett 19: 2107-11 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.019
BindingDB Entry DOI: 10.7270/Q26H4JB8 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Münster
Curated by ChEMBL
| Assay Description
Inhibition of human isolated cPLA2alpha by vescicle assay |
J Med Chem 49: 2611-20 (2006)
Article DOI: 10.1021/jm051243a
BindingDB Entry DOI: 10.7270/Q2668CSF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50185356
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-indole-5-car...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C26H31NO4/c1-2-3-4-5-6-7-8-20-9-12-24(13-10-20)31-19-23(28)18-27-16-15-21-17-22(26(29)30)11-14-25(21)27/h9-17H,2-8,18-19H2,1H3,(H,29,30) | PDB
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cPLA2-alpha activity |
Bioorg Med Chem 16: 3489-500 (2008)
Article DOI: 10.1016/j.bmc.2008.02.019
BindingDB Entry DOI: 10.7270/Q2W66MN0 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50308972
(1-Benzotriazol-1-yl-3-(4-octylphenoxy)propan-2-one...)Show InChI InChI=1S/C23H29N3O2/c1-2-3-4-5-6-7-10-19-13-15-21(16-14-19)28-18-20(27)17-26-23-12-9-8-11-22(23)24-25-26/h8-9,11-16H,2-7,10,17-18H2,1H3 | PDB
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PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of FAAH from rat brain microsomes by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233836
(CHEMBL4100466)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCOC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C33H43NO6/c1-3-4-5-6-7-9-12-25-14-17-28(18-15-25)40-24-27(35)22-34-23-30(32(36)13-10-8-11-20-39-2)29-21-26(33(37)38)16-19-31(29)34/h14-19,21,23H,3-13,20,22,24H2,1-2H3,(H,37,38) | PDB
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PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50110846
(4-(3-(4-(decyloxy)phenoxy)-2-oxopropoxy)benzoic ac...)Show SMILES CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C26H34O6/c1-2-3-4-5-6-7-8-9-18-30-23-14-16-25(17-15-23)32-20-22(27)19-31-24-12-10-21(11-13-24)26(28)29/h10-17H,2-9,18-20H2,1H3,(H,28,29) | PDB
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PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of FAAH from rat brain microsomes by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50233838
(CHEMBL1800992)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC)c3cc(ccc23)C(O)=O)cc1 Show InChI InChI=1S/C32H41NO5/c1-3-5-7-8-9-11-12-24-14-17-27(18-15-24)38-23-26(34)21-33-22-29(31(35)13-10-6-4-2)28-20-25(32(36)37)16-19-30(28)33/h14-20,22H,3-13,21,23H2,1-2H3,(H,36,37) | PDB
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of human platelet cytosolic phospholipase alpha-2 using 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine/1,2-dioleoyl-sn-glycerol as ... |
Eur J Med Chem 125: 1107-1114 (2017)
Article DOI: 10.1016/j.ejmech.2016.10.039
BindingDB Entry DOI: 10.7270/Q2DB8448 |
More data for this
Ligand-Target Pair | |
Cytosolic phospholipase A2
(Homo sapiens (Human)) | BDBM50277797
(1-(3-(4-octylphenoxy)-2-oxopropyl)-1H-benzo[d]imid...)Show SMILES CCCCCCCCc1ccc(OCC(=O)Cn2cnc3ccc(cc23)C(O)=O)cc1 Show InChI InChI=1S/C25H30N2O4/c1-2-3-4-5-6-7-8-19-9-12-22(13-10-19)31-17-21(28)16-27-18-26-23-14-11-20(25(29)30)15-24(23)27/h9-15,18H,2-8,16-17H2,1H3,(H,29,30) | PDB
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PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
University of M£nster
Curated by ChEMBL
| Assay Description
Inhibition of cPLA2 from human platelets by RP-HPLC |
Bioorg Med Chem 18: 945-52 (2010)
Article DOI: 10.1016/j.bmc.2009.11.028
BindingDB Entry DOI: 10.7270/Q2N016MF |
More data for this
Ligand-Target Pair | |
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