Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50376618 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_477674 (CHEMBL924740) |
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IC50 | 53800±n/a nM |
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Citation | Holmes, CP; Li, X; Pan, Y; Xu, C; Bhandari, A; Moody, CM; Miguel, JA; Ferla, SW; De Francisco, MN; Frederick, BT; Zhou, S; Macher, N; Jang, L; Irvine, JD; Grove, JR PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold. Bioorg Med Chem Lett18:2719-24 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50376618 |
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n/a |
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Name | BDBM50376618 |
Synonyms: | CHEMBL258463 |
Type | Small organic molecule |
Emp. Form. | C24H20ClN3O5S2 |
Mol. Mass. | 530.016 |
SMILES | OC(=O)COc1ccc(CN(Cc2ccc(cc2)-c2csnn2)S(=O)(=O)c2ccccc2)cc1Cl |
Structure |
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