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TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial
LigandBDBM50228363
Substrate/Competitorn/a
Meas. Tech.ChEMBL_479068 (CHEMBL933819)
EC50>300000±n/a nM
Citation Milne, JC; Lambert, PD; Schenk, S; Carney, DP; Smith, JJ; Gagne, DJ; Jin, L; Boss, O; Perni, RB; Vu, CB; Bemis, JE; Xie, R; Disch, JS; Ng, PY; Nunes, JJ; Lynch, AV; Yang, H; Galonek, H; Israelian, K; Choy, W; Iffland, A; Lavu, S; Medvedik, O; Sinclair, DA; Olefsky, JM; Jirousek, MR; Elliott, PJ; Westphal, CH Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature450:712-716 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Name:NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:Protein
Mol. Mass.:43582.69
Organism:Homo sapiens (Human)
Description:Q9NTG7
Residue:399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50228363
n/a
NameBDBM50228363
Synonyms:CHEMBL257991 | N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide | SRT-1720
TypeSmall organic molecule
Emp. Form.C25H23N7OS
Mol. Mass.469.561
SMILESO=C(Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1)c1cnc2ccccc2n1
Structure
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