| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Ligand | BDBM50377089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479301 (CHEMBL933673) |
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| IC50 | 800±n/a nM |
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| Citation |  Tipparaju, SK; Joyasawal, S; Forrester, S; Mulhearn, DC; Pegan, S; Johnson, ME; Mesecar, AD; Kozikowski, AP Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorg Med Chem Lett18:3565-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI |
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| Synonyms: | CSI15 | Cold shock-induced protein 15 | ENR | Enoyl-[acyl-carrier-protein] reductase [NADH] | Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | FABI_BACSU | NADH-dependent enoyl-ACP reductase | VEG241 | Vegetative protein 241 | fabI | yjbW |
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| Type: | PROTEIN |
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| Mol. Mass.: | 27870.90 |
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| Organism: | Bacillus subtilis (strain 168) |
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| Description: | ChEMBL_479301 |
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| Residue: | 258 |
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| Sequence: | MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGERLEKSVHELAGTLDRND
SIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEELVGEYLNTNRDGFLLAHN
ISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNVMGVAKASLDASVKYLAADLG
KENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPLRRTTTPEEVGDTAAFLFSDMSR
GITGENLHVDSGFHITAR
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| BDBM50377089 |
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| n/a |
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| Name | BDBM50377089 |
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| Synonyms: | CHEMBL261638 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21ClN2O2 |
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| Mol. Mass. | 392.878 |
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| SMILES | Clc1ccccc1Cn1ccc(OCCCn2ccc3ccccc23)cc1=O |
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| Structure | 
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