Reaction Details | |||
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Target | Mineralocorticoid receptor | ||
Ligand | BDBM50377349 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_479548 (CHEMBL931544) | ||
Ki | 155±n/a nM | ||
Citation | Roach, SL; Higuchi, RI; Adams, ME; Liu, Y; Karanewsky, DS; Marschke, KB; Mais, DE; Miner, JN; Zhi, L Discovery of nonsteroidal glucocorticoid receptor ligands based on 6-indole-1,2,3,4-tetrahydroquinolines. Bioorg Med Chem Lett18:3504-8 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mineralocorticoid receptor | |||
Name: | Mineralocorticoid receptor | ||
Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 107076.42 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08235 | ||
Residue: | 984 | ||
Sequence: |
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BDBM50377349 | |||
n/a | |||
Name | BDBM50377349 | ||
Synonyms: | CHEMBL253745 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H25ClN2O | ||
Mol. Mass. | 368.9 | ||
SMILES | COc1ccc2cc[nH]c2c1-c1cc(C)c2NC(C)(C)CC(C)c2c1Cl |w:21.23,(12.35,-42.62,;12.35,-44.16,;11.02,-44.93,;9.69,-44.17,;8.36,-44.94,;8.37,-46.49,;7.24,-47.52,;7.87,-48.91,;9.39,-48.74,;9.7,-47.25,;11.03,-46.48,;12.36,-47.25,;12.36,-48.8,;13.69,-49.57,;13.69,-51.11,;15.02,-48.8,;16.36,-49.58,;17.71,-48.8,;18.1,-50.28,;19.19,-48.4,;17.71,-47.25,;16.37,-46.46,;16.37,-44.92,;15.03,-47.24,;13.68,-46.48,;13.68,-44.94,)| | ||
Structure |