| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A3 |
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| Ligand | BDBM50163004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_479904 (CHEMBL935757) |
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| Ki | 2.8±n/a nM |
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| Citation |  Melman, A; Gao, ZG; Kumar, D; Wan, TC; Gizewski, E; Auchampach, JA; Jacobson, KA Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists. Bioorg Med Chem Lett18:2813-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A3 |
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| Name: | Adenosine receptor A3 |
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| Synonyms: | A3AR | AA3R_MOUSE | Adenosine A3 receptor | Adora3 | Gpcr2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36460.91 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1515686 |
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| Residue: | 319 |
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| Sequence: | MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADI
AVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYR
TVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVF
FSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLF
ALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRA
VRLCQTSDSLDSNMEQTTE
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| BDBM50163004 |
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| n/a |
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| Name | BDBM50163004 |
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| Synonyms: | (1S,2R,3S,4R,5S)-4-(2-chloro-6-(2-phenylcyclopropylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide | 1N-methyl-4-[2-chloro-6-(2-phenylcyclopropylamino)-9H-9-purinyl]-2,3-dihydroxy-(1S,2R,3S,4R,5S)-bicyclo[3.1.0]hexane-1-carboxamide | CHEMBL411861 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23ClN6O3 |
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| Mol. Mass. | 454.909 |
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| SMILES | CNC(=O)[C@]12C[C@@H]1[C@H]([C@H](O)[C@@H]2O)n1cnc2c(NC3CC3c3ccccc3)nc(Cl)nc12 |
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| Structure | 
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