Ki Summary

Reaction Details

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Target

Prolyl endopeptidase

Ligand

BDBM50241261

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_526176 (CHEMBL973892)

IC50

36320±n/a nM

Citation

Atta-ur-Rahman, A; Naz, H; Fadimatou, na; Makhmoor, T; Yasin, A; Fatima, N; Ngounou, FN; Kimbu, SF; Sondengam, BL; Choudhary, MI Bioactive constituents from Boswellia papyrifera. J Nat Prod68:189-93 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prolyl endopeptidase

Name:

Prolyl endopeptidase

Synonyms:

PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase

Type:

Enzyme

Mol. Mass.:

80688.50

Organism:

Homo sapiens (Human)

Description:

P48147

Residue:

710

Sequence:

MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP

BDBM50241261

n/a

Name

BDBM50241261

Synonyms:

(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid | 11-keto boswellic acid | 11-keto-beta-boswellic acid | 11-keto-beta-boswellicacid | CHEMBL437964

Type

Small organic molecule

Emp. Form.

C30H46O4

Mol. Mass.

470.6838

SMILES

C[C@@H]1CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2[C@H]1C |r,c:10|

Structure