Reaction Details |
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Target | Excitatory amino acid transporter 2 |
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Ligand | BDBM50252048 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_487937 (CHEMBL1016591) |
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Ki | 180000±n/a nM |
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Citation | Sagot, E; Jensen, AA; Pickering, DS; Pu, X; Umberti, M; Stensbøl, TB; Nielsen, B; Assaf, Z; Aboab, B; Bolte, J; Gefflaut, T; Bunch, L Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2. J Med Chem51:4085-92 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Excitatory amino acid transporter 2 |
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Name: | Excitatory amino acid transporter 2 |
Synonyms: | EAA2_HUMAN | EAAT2 | GLT1 | Glutamate/aspartate transporter II | SLC1A2 | Sodium-dependent glutamate/aspartate transporter 2 | Solute carrier family 1 member 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 62103.57 |
Organism: | Homo sapiens (Human) |
Description: | Excitatory Amino Acid EAAT2 0 0::P43004 |
Residue: | 574 |
Sequence: | MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC
GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA
MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL
VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM
NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI
IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG
TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL
DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS
VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA
AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
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BDBM50252048 |
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n/a |
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Name | BDBM50252048 |
Synonyms: | (2S,4R)-2-amino-4-(3-methoxy-3-oxopropyl)pentanedioic acid | (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic Acid | CHEMBL482080 |
Type | Small organic molecule |
Emp. Form. | C9H15NO6 |
Mol. Mass. | 233.2185 |
SMILES | COC(=O)CC[C@H](C[C@H](N)C(O)=O)C(O)=O |r| |
Structure |
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