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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50251932 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_488009 (CHEMBL1013888) | ||
| IC50 | 3±n/a nM | ||
| Citation |  Laufer, SA; Hauser, DR; Domeyer, DM; Kinkel, K; Liedtke, AJ Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. J Med Chem51:4122-49 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM50251932 | |||
| n/a | |||
| Name | BDBM50251932 | ||
| Synonyms: | CHEMBL516607 | trans-4-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-ylamino}-cyclohexanol | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23FN4OS | ||
| Mol. Mass. | 398.497 | ||
| SMILES | CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(N[C@H]2CC[C@H](O)CC2)c1 |r,wU:23.25,wD:20.21,(13.12,-40.31,;12.35,-38.97,;10.81,-38.97,;9.9,-40.21,;8.44,-39.73,;8.44,-38.19,;9.91,-37.72,;7.11,-37.41,;7.13,-35.87,;5.8,-35.09,;4.46,-35.85,;3.13,-35.08,;4.45,-37.4,;5.78,-38.17,;7.11,-40.5,;5.77,-39.72,;4.44,-40.49,;4.44,-42.04,;5.78,-42.8,;5.79,-44.35,;7.13,-45.11,;7.12,-46.65,;8.45,-47.42,;9.79,-46.65,;11.12,-47.42,;9.79,-45.11,;8.45,-44.33,;7.11,-42.03,)| | ||
| Structure | 
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