Reaction Details |
| Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase 1 |
---|
Ligand | BDBM50244328 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_555345 (CHEMBL954745) |
---|
IC50 | 3800±n/a nM |
---|
Citation | Schuster, D; Nashev, LG; Kirchmair, J; Laggner, C; Wolber, G; Langer, T; Odermatt, A Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. J Med Chem51:4188-99 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase 1 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
Type: | Enzyme |
Mol. Mass.: | 32409.16 |
Organism: | Homo sapiens (Human) |
Description: | P28845 |
Residue: | 292 |
Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
|
|
|
BDBM50244328 |
---|
n/a |
---|
Name | BDBM50244328 |
Synonyms: | CHEMBL469909 | N'-((3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-1,3,4,7,8,9,10,11,12,13-decahydro-2H-cyclopenta[a]phenanthren-17(14H)-ylidene)-4-methylbenzenesulfonohydrazide |
Type | Small organic molecule |
Emp. Form. | C26H34N2O3S |
Mol. Mass. | 454.625 |
SMILES | Cc1ccc(cc1)S(=O)(=O)NN=C1C=C[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r,w:11.11,c:14,t:19| |
Structure |
|