| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transporter |
|---|
| Ligand | BDBM35226 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_491868 (CHEMBL946205) |
|---|
| IC50 | 3.1±n/a nM |
|---|
| Citation |  Zhang, M; Jovic, F; Vickers, T; Dyck, B; Tamiya, J; Grey, J; Tran, JA; Fleck, BA; Pick, R; Foster, AC; Chen, C Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors. Bioorg Med Chem Lett18:3682-6 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transporter |
|---|
| Name: | Transporter |
|---|
| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69236.90 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Q63380 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
|
|
|
|---|
| BDBM35226 |
|---|
| n/a |
|---|
| Name | BDBM35226 |
|---|
| Synonyms: | (S,S)-reboxetine | Reboxetine | Vestra |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23NO3 |
|---|
| Mol. Mass. | 313.3908 |
|---|
| SMILES | CCOc1ccccc1O[C@H]([C@@H]1CNCCO1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
