Reaction Details |
| Report a problem with these data |
Target | 5-hydroxytryptamine receptor 1A |
---|
Ligand | BDBM50274784 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_536733 (CHEMBL984527) |
---|
Ki | 0.93±n/a nM |
---|
Citation | Hatzenbuhler, NT; Baudy, R; Evrard, DA; Failli, A; Harrison, BL; Lenicek, S; Mewshaw, RE; Saab, A; Shah, U; Sze, J; Zhang, M; Zhou, D; Chlenov, M; Kagan, M; Golembieski, J; Hornby, G; Lai, M; Smith, DL; Sullivan, KM; Schechter, LE; Andree, TH Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. J Med Chem51:6980-7004 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
5-hydroxytryptamine receptor 1A |
---|
Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
Type: | n/a |
Mol. Mass.: | 46122.49 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 422 |
Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
|
|
|
BDBM50274784 |
---|
n/a |
---|
Name | BDBM50274784 |
Synonyms: | 3-{[3-(5-Fluoro-1H-indol-3-yl)propyl](propyl)amino}chromane-5-carboxamide | CHEMBL516158 |
Type | Small organic molecule |
Emp. Form. | C24H28FN3O2 |
Mol. Mass. | 409.4964 |
SMILES | CCCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2cccc(C(N)=O)c2C1 |r| |
Structure |
|