Reaction Details |
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Target | Carbonic anhydrase 5B, mitochondrial |
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Ligand | BDBM50256567 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_519587 (CHEMBL943662) |
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Ki | 4500±n/a nM |
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Citation | Smaine, FZ; Pacchiano, F; Rami, M; Barragan-Montero, V; Vullo, D; Scozzafava, A; Winum, JY; Supuran, CT Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV. Bioorg Med Chem Lett18:6332-5 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 5B, mitochondrial |
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Name: | Carbonic anhydrase 5B, mitochondrial |
Synonyms: | CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB) |
Type: | Enzyme |
Mol. Mass.: | 36440.83 |
Organism: | Homo sapiens (Human) |
Description: | Human (cloned) isozyme |
Residue: | 317 |
Sequence: | MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPG
GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPL
EHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVI
GVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLS
ESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
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BDBM50256567 |
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n/a |
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Name | BDBM50256567 |
Synonyms: | CHEMBL482149 | N-[5-(4-bromophenyl)-1,3,4-thiadiazol-2-yl]sulfamide |
Type | Small organic molecule |
Emp. Form. | C8H7BrN4O2S2 |
Mol. Mass. | 335.201 |
SMILES | NS(=O)(=O)Nc1nnc(s1)-c1ccc(Br)cc1 |
Structure |
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