| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50276037 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496821 (CHEMBL1008834) |
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| IC50 | 140±n/a nM |
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| Citation |  Pescatore, G; Kinzel, O; Attenni, B; Cecchetti, O; Fiore, F; Fonsi, M; Rowley, M; Schultz-Fademrecht, C; Serafini, S; Steinkühler, C; Jones, P Optimization of a series of potent and selective ketone histone deacetylase inhibitors. Bioorg Med Chem Lett18:5528-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50276037 |
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| n/a |
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| Name | BDBM50276037 |
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| Synonyms: | (S)-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)octyl)thiazole-5-carboxamide | CHEMBL469741 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N4O2S |
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| Mol. Mass. | 396.506 |
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| SMILES | CC(=O)CCCCC[C@H](NC(=O)c1cncs1)c1nc(c[nH]1)-c1ccccc1 |r| |
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| Structure | 
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