Reaction Details |
| Report a problem with these data |
Target | Microsomal triglyceride transfer protein large subunit |
---|
Ligand | BDBM50107786 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_540455 (CHEMBL1029072) |
---|
IC50 | 3.5±n/a nM |
---|
Citation | Peukert, S; Jain, RK; Geisser, A; Sun, Y; Zhang, R; Bourret, A; Carlson, A; Dasilva, J; Ramamurthy, A; Kelleher, JF Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett19:328-31 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Microsomal triglyceride transfer protein large subunit |
---|
Name: | Microsomal triglyceride transfer protein large subunit |
Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
Type: | PROTEIN |
Mol. Mass.: | 99365.65 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_971724 |
Residue: | 894 |
Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
|
|
|
BDBM50107786 |
---|
n/a |
---|
Name | BDBM50107786 |
Synonyms: | (R)-6-methyl-N-(2-(pyridin-2-ylmethylamino)-2,3-dihydro-1H-inden-5-yl)-4'-(trifluoromethyl)biphenyl-2-carboxamide | 6-Methyl-4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-[(pyridin-2-ylmethyl)-amino]-indan-5-yl}-amide | CHEMBL356310 |
Type | Small organic molecule |
Emp. Form. | C30H26F3N3O |
Mol. Mass. | 501.5421 |
SMILES | Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NCc2ccccn2)c1-c1ccc(cc1)C(F)(F)F |r| |
Structure |
|