| Reaction Details |
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 | Report a problem with these data |
| Target | Growth factor receptor-bound protein 2 |
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| Ligand | BDBM50294418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_575368 (CHEMBL1027042) |
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| Kd | 1420±n/a nM |
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| Citation |  Jiang, S; Liao, C; Bindu, L; Yin, B; Worthy, KW; Fisher, RJ; Burke, TR; Nicklaus, MC; Roller, PP Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg Med Chem Lett19:2693-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth factor receptor-bound protein 2 |
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| Name: | Growth factor receptor-bound protein 2 |
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| Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 25205.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62993 |
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| Residue: | 217 |
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| Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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| BDBM50294418 |
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| n/a |
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| Name | BDBM50294418 |
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| Synonyms: | 4-{[(9S,15R,18S,21S)-15-carbamoyl-21-(carbamoylmethyl)-8,11,17,20,23-pentaoxo-18-(propan-2-yl)-13-thia-7,10,16,19,22-pentaazaspiro[5.17]tricosan-9-yl]methyl}phenoxyphosphonic acid | CHEMBL558991 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H44N7O11PS |
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| Mol. Mass. | 741.749 |
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| SMILES | CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C2(CCCCC2)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(=O)CSC[C@H](NC1=O)C(N)=O |r| |
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| Structure | 
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