| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Ligand | BDBM50368147 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_579410 (CHEMBL1053165) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Hosoda, S; Matsuda, D; Tomoda, H; Hashimoto, M; Aoyama, H; Hashimoto, Y Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors. Bioorg Med Chem Lett19:4228-31 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
|---|
| Synonyms: | HMDH_RAT | HMG-CoA reductase | Hmgcr |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 96689.85 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Isolated rat liver microsomes were used as enzyme source. |
|---|
| Residue: | 887 |
|---|
| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTAEQSKVSLGLAEDVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
PKKAQDNCCRREPLLVRRNQKLSSVEEDPGVNQDRKVEVIKPLVAEAETSGRATFVLGAS
AASPPLALGAQEPGIELPSEPRPNEECLQILESAEKGAKFLSDAEIIQLVNAKHIPAYKL
ETLMETHERGVSIRRQLLSAKLAEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVA
GPLCLDGKEYQVPMATTEGCLVASTNRGCRAISLGGGASSRVLADGMSRGPVVRLPRACD
SAEVKSWLETPEGFAVVKEAFDSTSRFARLQKLHVTLAGRNLYIRLQSKTGDAMGMNMIS
KGTEKALLKLQEFFPELQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVL
KTTTEAMVDVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLM
EASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARI
VCGTVMAGELSLMAALAAGHLVRSHMVHNRSKINLQDLQGTCTKKAA
|
|
|
|---|
| BDBM50368147 |
|---|
| n/a |
|---|
| Name | BDBM50368147 |
|---|
| Synonyms: | (+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | CHEMBL1078 | FLUVASTATIN SODIUM | Fluvastatin | cid_23663976 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25FNO4 |
|---|
| Mol. Mass. | 410.4586 |
|---|
| SMILES | CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
