| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50299579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592387 (CHEMBL1036960) |
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| Ki | 4800±n/a nM |
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| Citation |  Lopez, M; Paul, B; Hofmann, A; Morizzi, J; Wu, QK; Charman, SA; Innocenti, A; Vullo, D; Supuran, CT; Poulsen, SA S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J Med Chem52:6421-32 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50299579 |
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| n/a |
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| Name | BDBM50299579 |
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| Synonyms: | (2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxane-2-sulfonamide | (2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-sulfonamide | CHEMBL569412 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H13NO7S |
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| Mol. Mass. | 243.235 |
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| SMILES | NS(=O)(=O)[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O |r| |
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| Structure | 
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