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TargetCDK2/Cyclin E/G1/S-specific cyclin E2
LigandBDBM50378293
Substrate/Competitorn/a
Meas. Tech.ChEMBL_589413
IC50 0.06±n/a nM
Citation Trova MPBarnes KDAlicea LBenanti TBielaska MBilotta JBliss BDuong TNHaydar SHerr RJHui YJohnson MLehman JMPeace DRainka MSnider PSalamone STregay SZheng XFriedrich TD Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II. Bioorg Med Chem Lett 19:6613-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
CDK2/Cyclin E/G1/S-specific cyclin E2
Name:CDK2/Cyclin E/G1/S-specific cyclin E2
Synonyms:Cyclin-dependent kinase 2/G1/S-specific cyclin E1 /G1/S-specific cyclin E2 | Cyclin-dependent kinase 2/cyclin E
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 52510
Components:This complex has 3 components.
Component 1
Name:CDK3/cyclin E
Synonyms:G1/S-specific cyclin-E2
Type:PROTEIN
Mol. Mass.:46763.82
Organism:Homo sapiens (Human)
Description:EBI_10135
Residue:404
Sequence:
MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP
VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK
ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI
NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP
VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA
LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH
TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH
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Component 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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Component 3
Name:G1/S-specific cyclin-E1
Synonyms:CCNE | CCNE1
Type:Enzyme Subunit
Mol. Mass.:47073.17
Organism:Homo sapiens (Human)
Description:n/a
Residue:410
Sequence:
MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA
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BDBM50378293
n/a
NameBDBM50378293
Synonyms:CHEMBL566550
TypeSmall organic molecule
Emp. Form.C23H29N7S2
Mol. Mass.467.653
SMILESCC(C)n1cnc2c(NCc3ccc(s3)-c3cccs3)nc(N[C@H]3CC[C@H](N)CC3)nc12 |r,wU:23.24,wD:26.28,(29.82,-30.94,;30.84,-29.79,;32.35,-30.1,;30.35,-28.33,;31.24,-27.08,;30.33,-25.84,;28.87,-26.33,;27.54,-25.57,;27.53,-24.03,;26.19,-23.27,;24.86,-24.05,;24.71,-25.59,;23.2,-25.91,;22.43,-24.58,;23.45,-23.43,;20.89,-24.59,;19.98,-25.84,;18.52,-25.36,;18.52,-23.82,;19.98,-23.35,;26.21,-26.35,;26.21,-27.89,;24.88,-28.66,;24.89,-30.2,;26.22,-30.96,;26.22,-32.51,;24.89,-33.28,;24.89,-34.82,;23.55,-32.51,;23.55,-30.98,;27.55,-28.65,;28.89,-27.87,)|
Structure
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