Ki Summary

Reaction Details

Report a problem with these data

Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50301141

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_598563 (CHEMBL1043555)

EC50

7280±n/a nM

Citation

Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ Semi-rigid tripeptide agonists of melanocortin receptors. Bioorg Med Chem Lett19:5176-81 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50301141

n/a

Name

BDBM50301141

Synonyms:

(S)-2-((R)-2-((S)-2-(3-(benzo[d][1,3]dioxol-4-yl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide | CHEMBL570903

Type

Small organic molecule

Emp. Form.

C31H39N9O6

Mol. Mass.

633.6981

SMILES

NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2OCOc12)C(N)=O |r,wU:22.30,7.7,wD:11.19,(32.56,-30.51,;31.22,-29.74,;31.23,-28.2,;29.89,-30.51,;28.55,-29.75,;27.22,-30.52,;25.89,-29.75,;25.89,-28.21,;24.55,-27.44,;23.22,-28.21,;23.22,-29.75,;21.89,-27.44,;21.89,-25.9,;20.55,-25.13,;20.55,-23.59,;19.22,-22.82,;17.89,-23.59,;17.89,-25.13,;19.22,-25.9,;20.55,-28.21,;20.56,-29.75,;21.9,-30.52,;19.23,-30.52,;17.9,-29.75,;16.56,-30.52,;15.16,-29.89,;14.13,-31.04,;14.9,-32.36,;16.4,-32.05,;19.22,-32.06,;20.56,-32.82,;21.89,-32.05,;20.56,-34.36,;19.22,-35.13,;19.22,-36.67,;20.55,-37.43,;20.56,-38.96,;19.22,-39.74,;17.88,-38.97,;16.41,-39.45,;15.51,-38.2,;16.41,-36.95,;17.88,-37.42,;27.22,-27.44,;28.55,-28.21,;27.22,-25.9,)|

Structure