Reaction Details |
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Target | DNA topoisomerase (ATP-hydrolyzing) |
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Ligand | BDBM50378427 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_598031 (CHEMBL1046300) |
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IC50 | 367±n/a nM |
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Citation | Starr, JT; Sciotti, RJ; Hanna, DL; Huband, MD; Mullins, LM; Cai, H; Gage, JW; Lockard, M; Rauckhorst, MR; Owen, RM; Lall, MS; Tomilo, M; Chen, H; McCurdy, SP; Barbachyn, MR 5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett19:5302-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase (ATP-hydrolyzing) |
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Name: | DNA topoisomerase (ATP-hydrolyzing) |
Synonyms: | ParE |
Type: | PROTEIN |
Mol. Mass.: | 70593.66 |
Organism: | Streptococcus pneumoniae |
Description: | ChEMBL_598031 |
Residue: | 638 |
Sequence: | NYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDVTIN
KDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNL
SSSWLEVEITRDGAIYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDAGIFSTTDFK
YNTISERLNESAFLLKNVTLSLTDKRTDESVEFHYENGVQDFVSYLNEDKETLTPVLYFE
GEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMNDYARKTGLLK
EKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIVADKLTFFLM
ENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQSKNPAKNEL
YLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAKAKMADILKNEEINTMIYTIGAGVGA
DFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEVGHVYIALPPLYKMSKGK
GKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPETRTLIRVTIE
DLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEEATVF
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BDBM50378427 |
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n/a |
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Name | BDBM50378427 |
Synonyms: | CHEMBL565572 |
Type | Small organic molecule |
Emp. Form. | C20H16F3N7O |
Mol. Mass. | 427.3825 |
SMILES | CCNC(=O)Nc1cn2c(cc(cc2n1)-c1cccnc1)-c1ncc(cn1)C(F)(F)F |
Structure |
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