Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50423645 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_598030 (CHEMBL1046299) |
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IC50 | 37±n/a nM |
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Citation | Starr, JT; Sciotti, RJ; Hanna, DL; Huband, MD; Mullins, LM; Cai, H; Gage, JW; Lockard, M; Rauckhorst, MR; Owen, RM; Lall, MS; Tomilo, M; Chen, H; McCurdy, SP; Barbachyn, MR 5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett19:5302-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | GYRB_STRPN | gyrB |
Type: | PROTEIN |
Mol. Mass.: | 72222.52 |
Organism: | Streptococcus pneumoniae |
Description: | ChEMBL_598030 |
Residue: | 648 |
Sequence: | MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLHHLVWEIVDNSIDEALA
GFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVFTVLHAGGKFGGGGYKVSG
GLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVADLEIVGDTDKTGTTVHFTPDP
KIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQGLEQTKHYHYEGGIASYVEYINE
NKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVMSFANNIHTHEGGTHEQGFRTALTR
VINDYARKNKLLKDNEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNR
LFSEAFSDFLMENPQIAKRIVEKGILAAKARVAAKRAREVTRKKSGLEISNLPGKLADCS
SNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLF
TAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQP
PIYGVKVGSEIKEYIQPGADQEIKLQEALARYSEGRTKPTIQRYKGLGEMDDHQLWETTM
DPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYSTLDV
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BDBM50423645 |
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n/a |
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Name | BDBM50423645 |
Synonyms: | Albamycin | Cathomycin | NOVOBIOCIN |
Type | Small organic molecule |
Emp. Form. | C31H36N2O11 |
Mol. Mass. | 612.6243 |
SMILES | [#6]-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6](-[#7])=O)-[#6@H](-[#8])-[#6@@H](-[#8]-c2ccc3c(-[#8])c(-[#7]-[#6](=O)-c4ccc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c4)c(=O)oc3c2-[#6])-[#8]C1([#6])[#6] |
Structure |
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