| Reaction Details |
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 | Report a problem with these data |
| Target | Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| Ligand | BDBM50301952 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598678 (CHEMBL1050759) |
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| IC50 | >10000±n/a nM |
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| Citation |  Mapelli, C; Natarajan, SI; Meyer, JP; Bastos, MM; Bernatowicz, MS; Lee, VG; Pluscec, J; Riexinger, DJ; Sieber-McMaster, ES; Constantine, KL; Smith-Monroy, CA; Golla, R; Ma, Z; Longhi, DA; Shi, D; Xin, L; Taylor, JR; Koplowitz, B; Chi, CL; Khanna, A; Robinson, GW; Seethala, R; Antal-Zimanyi, IA; Stoffel, RH; Han, S; Whaley, JM; Huang, CS; Krupinski, J; Ewing, WR Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity. J Med Chem52:7788-99 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| Name: | Parathyroid hormone/parathyroid hormone-related peptide receptor |
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| Synonyms: | PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | PTH1R | PTH1R_HUMAN | PTHR | PTHR1 | Parathyroid hormone 1 receptor | Parathyroid hormone receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66370.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | PARATHYROID HT1 0 HUMAN::Q03431 |
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| Residue: | 593 |
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| Sequence: | MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPA
SIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPL
GAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETRE
REVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVK
DAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWIL
VEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKK
WIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH
YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLA
LDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKP
GTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
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| BDBM50301952 |
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| n/a |
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| Name | BDBM50301952 |
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| Synonyms: | (3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-imidazol-5-yl)propanamido)-2-methylpropanamido)-3-((S)-1-((S)-1-amino-3-(2'-methylbiphenyl-4-yl)-1-oxopropan-2-ylamino)-3-(2'-ethyl-4'-methoxybiphenyl-4-yl)-1-oxopropan-2-ylcarbamoyl)-12-(2-fluorobenzyl)-9,15-bis((R)-1-hydroxyethyl)-6-(hydroxymethyl)-12-methyl-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatetracosane-1,24-dioic acid | CHEMBL577345 |
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| Type | Small organic molecule |
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| Emp. Form. | C76H95FN14O19 |
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| Mol. Mass. | 1527.6483 |
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| SMILES | CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2C)C(N)=O)cc1 |r| |
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| Structure | 
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